Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | HTR2B | P41595 | 3/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | RAF1 | P04049 | 7/20 | 0.35 |
| ▸ | IDH2 | P48735 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17769442 | 1.00 | HTR2A (0.38) | HTR2AHTR2CHTR2BTRPV1RAF1 | |
| SCHEMBL17778327 | 1.00 | HTR2A (0.38) | HTR2AHTR2CHTR2BTRPV1RAF1 | |
| SCHEMBL17778502 | 0.96 | HTR2A (0.39) | HTR2AHTR2CHTR2BTRPV1RAF1 | |
| SCHEMBL20550386 | 0.96 | HTR2A (0.39) | HTR2AHTR2CHTR2BTRPV1RAF1 | |
| SCHEMBL17778501 | 0.96 | HTR2A (0.39) | HTR2AHTR2CHTR2BTRPV1RAF1 | |
| SCHEMBL17769652 | 0.96 | HTR2A (0.39) | HTR2AHTR2CHTR2BTRPV1RAF1 | |
| SCHEMBL17778374 | 0.92 | TRPV1 (0.37) | TRPV1RAF1IDH2BRAFKDM4E | |
| SCHEMBL17769599 | 0.92 | TRPV1 (0.37) | TRPV1RAF1IDH2BRAFKDM4E | |
| SCHEMBL17769604 | 0.92 | TRPV1 (0.37) | TRPV1RAF1IDH2BRAFKDM4E | |
| SCHEMBL20550498 | 0.92 | TRPV1 (0.38) | TRPV1RAF1IDH2BRAFKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180319810-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2018-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180319810-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | HTR2A 4669/4885HTR2C 4746/4885HTR2B 4380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.