Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 18/20 | 0.82 |
| ▸ | SULT1A1 | P50225 | 4/20 | 0.82 |
| ▸ | MAPT | P10636 | 2/20 | 0.82 |
| ▸ | SNCA | P37840 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pittsburgh Compound B SCHEMBL29360193 | 0.90 | APP (1.00) | APPSULT1A1MAPTSNCA | |
| Pittsburgh Compound B Unlabelled SCHEMBL29409766 | 0.90 | APP (1.00) | APPSULT1A1MAPTSNCA | |
| Pittsburgh Compound B Unlabelled SCHEMBL912744 | 0.90 | APP (1.00) | APPSULT1A1MAPTSNCA | |
| Pittsburgh Compound B SCHEMBL2055285 | 0.90 | APP (1.00) | APPSULT1A1MAPTSNCA | |
| SCHEMBL12421903 | 0.83 | APP (0.85) | APPSULT1A1MAPTSNCA | |
| SCHEMBL5423269 | 0.82 | APP (0.81) | APPSULT1A1MAPT | |
| SCHEMBL2055208 | 0.82 | APP (0.84) | APPSULT1A1MAPT | |
| SCHEMBL19372620 | 0.81 | APP (0.73) | APPSULT1A1MAPTSNCA | |
| SCHEMBL19116022 | 0.81 | APP (0.69) | APPSULT1A1MAPT | |
| SCHEMBL2922465 | 0.80 | APP (0.72) | APPSULT1A1MAPTSNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120207679-A1 | Novel Heteroaryl Substituted Benzothiazoles | ASTRAZENECA AB (SE) | 2012-08-16 | — | — | US | disclosed |
| US-8163928-B2 | Heteroaryl substituted benzothiazoles | ASTRAZENECA AB (SE) | 2012-04-24 | — | — | US | disclosed |
| US-7772256-B2 | 2-heteroaryl substituted benzothiophenes and benzofuranes 709 | ASTRAZENECA AB (SE) | 2010-08-10 | — | — | US | disclosed |
| US-20100098631-A1 | Novel-2-Heteroaryl Substituted Indoles 695 | ASTRAZENECA AB (SE) | 2010-04-22 | — | — | US | disclosed |
| US-20100092385-A1 | Novel Heteroaryl Substituted Imidazo [1,2-A] Pyridine Derivatives | ASTRAZENECA AB (SE) | 2010-04-15 | — | — | US | disclosed |
| US-7670591-B2 | Heteroaryl substituted benzoxazoles | ASTRAZENECA AB (SE) | 2010-03-02 | — | — | US | disclosed |
| US-20090028787-A1 | Novel Heteroaryl Substituted Benzothiazoles | NAVIDEA BIOPHARMACEUTICALS, INC. | 2009-01-29 | — | — | US | disclosed |
| US-20080221149-A1 | 2-[6-(methylamino)pyridin-3-yl]-1-benzofuran-5-ol; for imaging amyloid deposits in living patients | ASTRAZENECA AB (SE) | 2008-09-11 | — | — | US | disclosed |
| US-20080027051-A1 | Novel Heteroaryl Substituted Benzoxazoles | ASTRAZENECA AB (SE) | 2008-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090028787-A1 | Novel Heteroaryl Substituted Benzothiazoles | APP, MAPT, PSEN1 | APP 1/4885SULT1A1 439/4885MAPT 2/4885 |
| US-20080027051-A1 | Novel Heteroaryl Substituted Benzoxazoles | PSEN1, PSEN2, APP | APP 3/4885SULT1A1 448/4885MAPT 6/4885 |
| US-20100092385-A1 | Novel Heteroaryl Substituted Imidazo [1,2-A] Pyridine Derivatives | APP, PSEN1, PSEN2 | APP 1/4885SULT1A1 1329/4885MAPT 4/4885 |
| US-20100098631-A1 | Novel-2-Heteroaryl Substituted Indoles 695 | APP, IDO2, IDO1 | APP 1/4885SULT1A1 1289/4885MAPT 7/4885 |
| US-20120207679-A1 | Novel Heteroaryl Substituted Benzothiazoles | MAPT, APP, PSEN1 | APP 2/4885SULT1A1 427/4885MAPT 1/4885 |
| US-20080221149-A1 | 2-[6-(methylamino)pyridin-3-yl]-1-benzofuran-5-ol; for imaging amyloid deposits in living patients | PSEN1, APP, PSEN2 | APP 2/4885SULT1A1 189/4885MAPT 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.