Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 19/20 | 1.00 |
| ▸ | SULT1A1 | P50225 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | SNCA | P37840 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pittsburgh Compound B SCHEMBL29360193 | 1.00 | APP (1.00) | APPSULT1A1MAPTSNCA | |
| Pittsburgh Compound B Unlabelled SCHEMBL912744 | 1.00 | APP (1.00) | APPSULT1A1MAPTSNCA | |
| Pittsburgh Compound B Unlabelled SCHEMBL29409766 | 1.00 | APP (1.00) | APPSULT1A1MAPTSNCA | |
| SCHEMBL12421903 | 0.92 | APP (0.85) | APPSULT1A1MAPTSNCA | |
| Pittsburgh Compound B Unlabelled SCHEMBL2055283 | 0.90 | APP (0.82) | APPSULT1A1MAPTSNCA | |
| SCHEMBL5423269 | 0.86 | APP (0.81) | APPSULT1A1MAPT | |
| SCHEMBL19372620 | 0.85 | APP (0.73) | APPSULT1A1MAPTSNCA | |
| SCHEMBL178156 | 0.84 | APP (1.00) | APPSULT1A1MAPTSNCA | |
| SCHEMBL2628262 | 0.84 | APP (1.00) | APPSULT1A1MAPTSNCA | |
| SCHEMBL2922465 | 0.83 | APP (0.72) | APPSULT1A1MAPTSNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130266513-A1 | IMAGING OF MENINGIOMAS USING PHINGYLBENZOTHIAZOLE, STILBENE, OR BIPHENYLALKYNE DERIVATIVES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2013-10-10 | — | — | US | disclosed |
| US-20120302603-A1 | AMYLOID BINDING AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-11-29 | — | — | US | disclosed |
| US-20120263646-A1 | IMAGING AGENTS AND THEIR USE FOR THE DIAGNOSTIC IN VIVO OF NEURODEGENERATIVE DISEASES, NOTABLY ALZHEIMER'S DISEASE AND DERIVATIVE DISEASES | GUERBET (FR) | 2012-10-18 | — | — | US | disclosed |
| US-20120214994-A1 | (3-FLUORO-2-HYDROXY)PROPYL-FUNCTIONALIZED ARYL DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR THE DIAGNOSIS OR TREATMENT OF NEURODEGENERATIVE BRAIN DISEASES | FUTURECHEM CO., LTD. (KR) | 2012-08-23 | — | — | US | disclosed |
| US-20120207679-A1 | Novel Heteroaryl Substituted Benzothiazoles | ASTRAZENECA AB (SE) | 2012-08-16 | — | — | US | disclosed |
| US-8163928-B2 | Heteroaryl substituted benzothiazoles | ASTRAZENECA AB (SE) | 2012-04-24 | — | — | US | disclosed |
| US-20110250136-A1 | FLUORINATED BENZOTHIAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND IMAGING AGENT FOR DIAGNOSING ALTZHEIMER'S DISEASE USING THE SAME | SNU R&DB FOUNDATION (KR) | 2011-10-13 | — | — | US | disclosed |
| US-20110008254-A1 | RADIOPHARMACEUTICAL COMPOSITION | GE HEALTHCARE LIMITED (GB) | 2011-01-13 | — | — | US | disclosed |
| US-20090028787-A1 | Novel Heteroaryl Substituted Benzothiazoles | NAVIDEA BIOPHARMACEUTICALS, INC. | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110008254-A1 | RADIOPHARMACEUTICAL COMPOSITION | SSTR3, SSTR5, SGMS1 | APP 812/4885SULT1A1 754/4885MAPT 1418/4885 |
| US-20090028787-A1 | Novel Heteroaryl Substituted Benzothiazoles | APP, MAPT, PSEN1 | APP 1/4885SULT1A1 439/4885MAPT 2/4885 |
| US-20120302603-A1 | AMYLOID BINDING AGENTS | APP, APBA1, PSEN1 | APP 1/4885SULT1A1 4621/4885MAPT 6/4885 |
| US-20110250136-A1 | FLUORINATED BENZOTHIAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND IMAGING AGENT FOR DIAGNOSING ALTZHEIMER'S DISEASE USING THE SAME | APBA1, APP, PSEN1 | APP 2/4885SULT1A1 594/4885MAPT 5/4885 |
| US-20120207679-A1 | Novel Heteroaryl Substituted Benzothiazoles | MAPT, APP, PSEN1 | APP 2/4885SULT1A1 427/4885MAPT 1/4885 |
| US-20120214994-A1 | (3-FLUORO-2-HYDROXY)PROPYL-FUNCTIONALIZED ARYL DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR THE DIAGNOSIS OR TREATMENT OF NEURODEGENERATIVE BRAIN DISEASES | APP, FABP7, SLC3A2 | APP 1/4885SULT1A1 2061/4885MAPT 40/4885 |
| US-20120263646-A1 | IMAGING AGENTS AND THEIR USE FOR THE DIAGNOSTIC IN VIVO OF NEURODEGENERATIVE DISEASES, NOTABLY ALZHEIMER'S DISEASE AND DERIVATIVE DISEASES | SNCA, PSEN2, CLN6 | APP 10/4885SULT1A1 4643/4885MAPT 4/4885 |
| US-20130266513-A1 | IMAGING OF MENINGIOMAS USING PHINGYLBENZOTHIAZOLE, STILBENE, OR BIPHENYLALKYNE DERIVATIVES | MEN1, BPHL, PSEN2 | APP 65/4885SULT1A1 2537/4885MAPT 224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.