Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.32 |
| ▸ | CDC25B | P30305 | 4/20 | 0.32 |
| ▸ | BCHE | P06276 | 2/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12243178 | 1.00 | PDE2A (0.35) | PDE2ATMPRSS2HTR1AHSPA5PTPN1 | |
| SCHEMBL20477154 | 1.00 | PDE2A (0.35) | PDE2ATMPRSS2HTR1AHSPA5PTPN1 | |
| SCHEMBL27086511 | 1.00 | PDE2A (0.35) | PDE2ATMPRSS2HTR1AHSPA5PTPN1 | |
| SCHEMBL29727834 | 1.00 | PDE2A (0.35) | PDE2ATMPRSS2HTR1AHSPA5PTPN1 | |
| SCHEMBL17712276 | 1.00 | PDE2A (0.35) | PDE2ATMPRSS2HTR1AHSPA5PTPN1 | |
| Maleic Acid SCHEMBL20552110 | 0.94 | TMPRSS2 (0.36) | PDE2ATMPRSS2HSPA5PTPN1CDC25B | |
| SCHEMBL24158032 | 0.92 | PDE2A (0.38) | PDE2ATMPRSS2HTR1AHSPA5PTPN1 | |
| SCHEMBL22646505 | 0.92 | PDE2A (0.38) | PDE2ATMPRSS2HTR1AHSPA5PTPN1 | |
| SCHEMBL14817042 | 0.92 | HSPA5 (0.35) | PDE2ATMPRSS2HTR1AHSPA5PTPN1 | |
| SCHEMBL12393267 | 0.91 | PDE2A (0.35) | PDE2AHTR1AHSPA5PTPN1CDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118852168-A | Novel method for preparing benzyl carbon nucleoside analogue on large scale and application thereof | 深圳科兴药业有限公司 | 2024-10-29 | — | — | CN | disclosed |
| US-12030906-B2 | Crystalline forms of (s)-2-ethylbutyl 2-(((s)-(((2r,3s,4r,5r)-5-(4-aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy) (phenoxy) phosphoryl)amino)propanoate | GILEAD SCIENCES, INC. (US) | 2024-07-09 | — | — | US | disclosed |
| US-20230348519-A1 | CRYSTALLINE FORMS OF (S)-2-ETHYLBUTYL 2-(((S)-(((2R,3S,4R,5R)-5- (4-AMINOPYRROLO[2,1-F] [1,2,4]TRIAZIN-7-YL)-5-CYANO-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHOXY) (PHENOXY) PHOSPHORYL)AMINO)PROPANOATE | GILEAD SCIENCES, INC. | 2023-11-02 | — | — | US | disclosed |
| EP-4219513-A1 | CRYSTALLINE FORM OF (S)-2-ETHYLBUTYL 2-(((S)-(((2R,3S,4R,5R)-5-(4-AMINOPYRROLO[2,1-F] [1,2,4]TRIAZIN-7-YL)-5-CYANO-3,4-DIHYDROXYTETRAHYDROFURAN2-YL)METHOXY)(PHENOXY) PHOSPHORYL)AMINO)PROPANOATE | Gilead Sciences, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| US-11597742-B2 | Crystalline forms of (S)-2-ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy) (phenoxy) phosphoryl)amino)propanoate | GILEAD SCIENCES, INC. (US) | 2023-03-07 | — | — | US | disclosed |
| EP-3618929-B1 | A CRYSTALLINE FORM OF (S) 2 ETHYLBUTYL 2 (((S) (((2R,3S,4R,5R) 5 (4 AMINOPYRROLO[2,1-F][1,2,4]TRIAZIN-7-YL)-5-CYANO-3,4-DIHYDROXYTETRAHYDROFURAN-2 YL)METHOXY)(PHENOXY) PHOSPHORYL)AMINO)PROPANOATE | GILEAD SCIENCES INC (US) | 2022-12-07 | — | — | EP | disclosed |
| CN-115403626-A | Novel crystalline forms | 吉利德科学公司 | 2022-11-29 | — | — | CN | disclosed |
| CN-110636884-B | Novel crystalline forms | 吉利德科学公司 | 2022-10-04 | — | — | CN | disclosed |
| US-20210163523-A1 | CRYSTALLINE FORMS OF (S)-2-ETHYLBUTYL 2-(((S)-(((2R,3S,4R,5R)-5- (4-AMINOPYRROLO[2,1-F] [1,2,4]TRIAZIN-7-YL)-5-CYANO-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHOXY) (PHENOXY) PHOSPHORYL)AMINO)PROPANOATE | GILEAD SCIENCES, INC. | 2021-06-03 | — | — | US | disclosed |
| US-10836787-B2 | Crystalline forms of (S)-2-ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5- (4-aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy) phosphoryl)amino)propanoate | GILEAD SCIENCES, INC. (US) | 2020-11-17 | — | — | US | disclosed |
| EP-3618929-A1 | CRYSTALLINE FORMS OF (S) 2 ETHYLBUTYL 2 (((S) (((2R,3S,4R,5R) 5 (4 AMINOPYRROLO[2,1-F][1,2,4]TRIAZIN-7-YL)-5-CYANO-3,4-DIHYDROXYTETRAHYDROFURAN-2 YL)METHOXY)(PHENOXY) PHOSPHORYL)AMINO)PROPANOATE | Gilead Sciences, Inc. (US) | 2020-03-11 | — | — | EP | disclosed |
| US-20180346504-A1 | CRYSTALLINE FORMS OF (S)-2-ETHYLBUTYL 2-(((S)-(((2R,3S,4R,5R)-5- (4-AMINOPYRROLO[2,1-F] [1,2,4]TRIAZIN-7-YL)-5-CYANO-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHOXY) (PHENOXY) PHOSPHORYL)AMINO)PROPANOATE | GILEAD SCIENCES, INC. | 2018-12-06 | — | — | US | disclosed |
| WO-2018204198-A1 | CRYSTALLINE FORMS OF (S) 2 ETHYLBUTYL 2 (((S) (((2R,3S,4R,5R) 5 (4 AMINOPYRROLO[2,1-F] [1,2,4]TRIAZIN-7-YL)-5-CYANO-3,4-DIHYDROXYTETRAHYDROFURAN-2 YL)METHOXY)(PHENOXY) PHOSPHORYL)AMINO)PROPANOATE | GILEAD SCIENCES, INC. (US) | 2018-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180346504-A1 | CRYSTALLINE FORMS OF (S)-2-ETHYLBUTYL 2-(((S)-(((2R,3S,4R,5R)-5- (4-AMINOPYRROLO[2,1-F] [1,2,4]TRIAZIN-7-YL)-5-CYANO-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHOXY) (PHENOXY) PHOSPHORYL)AMINO)PROPANOATE | SARS1, MTAP, PNP | PDE2A 1328/4885TMPRSS2 95/4885HTR1A 1091/4885 |
| US-12030906-B2 | Crystalline forms of (s)-2-ethylbutyl 2-(((s)-(((2r,3s,4r,5r)-5-(4-aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy) (phenoxy) phosphoryl)amino)propanoate | SARS1, MTAP, PNP | PDE2A 1328/4885TMPRSS2 95/4885HTR1A 1091/4885 |
| US-10836787-B2 | Crystalline forms of (S)-2-ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5- (4-aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy) phosphoryl)amino)propanoate | MTAP, SARS1, PNP | PDE2A 1157/4885TMPRSS2 229/4885HTR1A 1173/4885 |
| US-20210163523-A1 | CRYSTALLINE FORMS OF (S)-2-ETHYLBUTYL 2-(((S)-(((2R,3S,4R,5R)-5- (4-AMINOPYRROLO[2,1-F] [1,2,4]TRIAZIN-7-YL)-5-CYANO-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHOXY) (PHENOXY) PHOSPHORYL)AMINO)PROPANOATE | SARS1, MTAP, PNP | PDE2A 1328/4885TMPRSS2 95/4885HTR1A 1091/4885 |
| US-11597742-B2 | Crystalline forms of (S)-2-ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy) (phenoxy) phosphoryl)amino)propanoate | SARS1, MTAP, PNP | PDE2A 1328/4885TMPRSS2 95/4885HTR1A 1091/4885 |
| US-20230348519-A1 | CRYSTALLINE FORMS OF (S)-2-ETHYLBUTYL 2-(((S)-(((2R,3S,4R,5R)-5- (4-AMINOPYRROLO[2,1-F] [1,2,4]TRIAZIN-7-YL)-5-CYANO-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHOXY) (PHENOXY) PHOSPHORYL)AMINO)PROPANOATE | SARS1, MTAP, PNP | PDE2A 1328/4885TMPRSS2 95/4885HTR1A 1091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.