SCHEMBL205545

SCHEMBL205545

N[C@@H](C(=O)O)c1ccc(F)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 5/20 0.52
TDP1 Q9NUW8 4/20 0.52
MEN1 O00255 3/20 0.52
CYP2C9 P11712 3/20 0.52
KMT2A Q03164 3/20 0.52
CYP2C19 P33261 2/20 0.52
CYP2D6 P10635 1/20 0.52
GRM8 O00222 1/20 0.52
GRM6 O15303 1/20 0.52
SLC6A2 P23975 1/20 0.52
SLC6A4 P31645 1/20 0.52
DRD3 P35462 1/20 0.52
GRM4 Q14833 1/20 0.52
KDM4E B2RXH2 4/20 0.48
ALDH1A1 P00352 4/20 0.48
HPGD P15428 4/20 0.48
GRM1 Q13255 3/20 0.48
GRM2 Q14416 2/20 0.48
HDAC3 O15379 1/20 0.45
HDAC4 P56524 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL162203 1.00 HSD17B10 (0.52) HSD17B10TDP1MEN1CYP2C9KMT2A
SCHEMBL207638 1.00 HSD17B10 (0.52) HSD17B10TDP1MEN1CYP2C9KMT2A
Hydrochloric Acid SCHEMBL28010750 0.98 HSD17B10 (0.50) HSD17B10TDP1MEN1CYP2C9KMT2A
Hydrochloric Acid SCHEMBL23112808 0.98 HSD17B10 (0.50) HSD17B10TDP1MEN1CYP2C9KMT2A
Hydrochloric Acid SCHEMBL23112807 0.98 HSD17B10 (0.50) HSD17B10TDP1MEN1CYP2C9KMT2A
SCHEMBL30057645 0.94 BCL2L1 (0.50) HSD17B10TDP1MEN1CYP2C9KMT2A
SCHEMBL13527786 0.88 HSD17B10 (0.61) HSD17B10TDP1MEN1CYP2C9KMT2A
SCHEMBL6321555 0.82 HDAC3 (0.45) ALDH1A1HDAC3HDAC4HDAC1HDAC7
SCHEMBL10069409 0.82 HDAC3 (0.45) ALDH1A1HDAC3HDAC4HDAC1HDAC7
SCHEMBL5114354 0.82 HDAC3 (0.45) ALDH1A1HDAC3HDAC4HDAC1HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 194 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6432953-B1 None US disclosed
CN-117561244-A Isoindolinone compounds and uses thereof 杭州格博生物医药有限公司 2024-02-13 CN disclosed
CN-111718290-B Synthesis method of multi-configuration isoindoline-1-carboxylic acid amino acid compound 苏州爱玛特生物科技有限公司 2022-11-25 CN disclosed
EP-4013440-A1 THERAPEUTIC PEPTIDES Cohbar Inc. (US) 2022-06-22 EP disclosed
EP-3983543-A1 REAGENTS AND METHODS FOR REPLICATION, TRANSCRIPTION, AND TRANSLATION IN SEMI-SYNTHETIC ORGANISMS The Scripps Research Institute (US) 2022-04-20 EP disclosed
CN-114269367-A Therapeutic peptides 科巴公司 2022-04-01 CN disclosed
CN-106588890-B Antiviral compounds 吉利德制药有限责任公司 2020-11-27 CN disclosed
CN-111718290-A Synthesis method of multi-configuration isoindoline-1-carboxylic acid amino acid compound 苏州爱玛特生物科技有限公司 2020-09-29 CN disclosed
EP-3626716-A1 ANTIVIRAL COMPOUNDS Gilead Pharmasset LLC (US) 2020-03-25 EP disclosed
US-9981955-B2 Antiviral compounds GILEAD PHARMASSET LLC (US) 2018-05-29 US disclosed
US-6229010-B1 RECOVERING FORM I OF 2-(R)-(1-(R)-(3,5-BIS(TRIFLUOROMETHYL) -PHENYL)ETHOXY)-3-(S)-(4-FLUORO)PHENYL-4-(3-(5-OXO-1H,4H-1,2,4 -TRIAZOLO)METHYLMORPHOLINE FROM FORM II EQUILIBRATED IN ETHANOL, ISOPROPANOL, ACETONITRILE OR ISOPROPYL ACETATE MERCK & CO., INC. 2001-05-08 US disclosed
US-6096742-A Polymorphic form of a tachykinin receptor antagonist MERCK & CO., INC. (US) 2000-08-01 US disclosed
EP-0994867-A1 POLYMORPHIC FORM OF THE TACHYKININ RECEPTOR ANTAGONIST 2-(R)-(1-(R) -(3,5-BIS(TRIFLUOROMETHYL) PHENYL)ETHOXY)-3-(S)-(4-FLUORO) PHENYL-4-(3-5 (-OXO-1H,4H-1,2,4,-TRIAZOLO) METHYLMORPHOLINE Merck & Co., Inc. (US) 2000-04-26 EP disclosed
US-6048859-A ANTIEMETIC AGENT MERCK & CO., INC. (US) 2000-04-11 US disclosed
US-5922706-A TREATING INFLAMMATORY DISEASES, PAIN OR MIGRAINE, ASTHMA AND EMESIS, AND CALCIUM CHANNEL BLOCKERS USEFUL IN THE TREATMENT OF CARDIOVASCULAR DISORDERS SUCH AS ANGINA, HYPERTENSION OR ISCHEMIA MERCK & CO., INC. (US) 1999-07-13 US disclosed
US-5872116-A TREATMENT OF INFLAMATION, PAIN, MIGRAINE, ASTHMA AND EMESIS MERCK & CO., INC. (US) 1999-02-16 US disclosed
WO-1999001444-A1 POLYMORPHIC FORM OF THE TACHYKININ RECEPTOR ANTAGONIST 2-(R)-(1-(R) -(3,5-BIS(TRIFLUOROMETHYL) PHENYL)ETHOXY)-3-(S)-(4-FLUORO) PHENYL-4-(3-5 (-OXO-1H,4H-1,2,4,-TRIAZOLO) METHYLMORPHOLINE MERCK & CO., INC. (US) 1999-01-14 WO disclosed
US-5780467-A USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES, PAIN OR MIGRAINE, ASTHMA AND EMESIS MERCK & CO., INC. (US) 1998-07-14 US disclosed
US-5719147-A Morpholine and thiomorpholine tachykinin receptor antagonists MERCK & CO., INC. (US) 1998-02-17 US disclosed
US-5691336-A ANTIINFLAMMATORY AGENTS; ANALGESICS; THERAPY OF ASTHMA, EMESIS MERCK & CO., INC. (US) 1997-11-25 US disclosed