Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylphenylsulfide SCHEMBL28522981 | 1.00 | PTGS2 (0.44) | PTGS2KMT2AMEN1MAPTSMN1; SMN2 | |
| Methylphenylsulfide SCHEMBL6153558 | 0.85 | KMT2A (0.39) | PTGS2KMT2AMEN1MAPTSMN1; SMN2 | |
| Methylphenylsulfide SCHEMBL27970000 | 0.84 | MAPT (0.53) | PTGS2KMT2AMEN1MAPTSMN1; SMN2 | |
| Methylphenylsulfide SCHEMBL27951695 | 0.84 | MAPT (0.53) | PTGS2KMT2AMEN1MAPTSMN1; SMN2 | |
| Methylphenylsulfide SCHEMBL7584 | 0.84 | — | — | |
| Methylphenylsulfide SCHEMBL4902407 | 0.84 | — | — | |
| Methylphenylsulfide SCHEMBL1332325 | 0.84 | — | — | |
| Methylphenylsulfide SCHEMBL1335985 | 0.81 | MAPT (0.50) | PTGS2KMT2AMEN1MAPTSMN1; SMN2 | |
| Methylphenylsulfide SCHEMBL6233931 | 0.81 | — | — | |
| Methylphenylsulfide SCHEMBL4382713 | 0.81 | MAPT (0.50) | PTGS2KMT2AMEN1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3403651-B1 | ISOCORYDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | LANZHOU INST CHEMICAL PHYSICS CAS (CN) | 2019-10-30 | — | — | EP | claimed |
| US-20180334448-A1 | Isocorydine derivatives, preparation method and use thereof | LANZHOU INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCES (CN) | 2018-11-22 | — | — | US | claimed |
| EP-3403651-A1 | ISOCORYDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | Lanzhou Institute Of Chemical Physics Chinese Academy of Sciences (CN) | 2018-11-21 | — | — | EP | claimed |
| CN-114380874-B | Macrolide antibiotics, preparation method and application thereof | 中国医学科学院医药生物技术研究所 | 2024-06-21 | — | — | CN | disclosed |
| CN-107488146-B | Isocorydine derivative and preparation method and application thereof | 中国科学院兰州化学物理研究所 | 2020-05-22 | — | — | CN | disclosed |
| EP-3403651-B1 | ISOCORYDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | LANZHOU INST CHEMICAL PHYSICS CAS (CN) | 2019-10-30 | — | — | EP | disclosed |
| US-20180334448-A1 | Isocorydine derivatives, preparation method and use thereof | LANZHOU INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCES (CN) | 2018-11-22 | — | — | US | disclosed |
| EP-3403651-A1 | ISOCORYDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | Lanzhou Institute Of Chemical Physics Chinese Academy of Sciences (CN) | 2018-11-21 | — | — | EP | disclosed |
| CN-108475514-A | Kit containing sealant and photopolymer | 科思创德国股份有限公司 | 2018-08-31 | — | — | CN | disclosed |
| CN-107922360-A | Substituted triazines and process for their preparation | 科思创德国股份有限公司 | 2018-04-17 | — | — | CN | disclosed |
| CN-107438515-A | Method for producing an optical cast with a holographic optical element and optical cast | 科思创德国股份有限公司 | 2017-12-05 | — | — | CN | disclosed |
| CN-107223121-A | Wet stable holographic media | 科思创德国股份有限公司 | 2017-09-29 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180334448-A1 | Isocorydine derivatives, preparation method and use thereof | CCND2, CCND3, IDH3A | PTGS2 477/4885KMT2A 2096/4885MEN1 187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.