SCHEMBL20560699

SCHEMBL20560699

Fc1ccc(NC(=S)Cl)cc1Cl

nearest known ligand 0.76

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 10/20 0.76
MEN1 O00255 8/20 0.76
MAPT P10636 6/20 0.76
ALDH1A1 P00352 6/20 0.76
HTT P42858 3/20 0.76
NPSR1 Q6W5P4 1/20 0.76
SLC2A1 P11166 1/20 0.59
TSHR P16473 1/20 0.56
LMNA P02545 5/20 0.55
KDM4E B2RXH2 1/20 0.55
NPC1 O15118 2/20 0.54
RAB9A P51151 2/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
NR1I2 O75469 1/20 0.54
AHR P35869 1/20 0.54
GAA P10253 3/20 0.52
PLA2G1B P04054 1/20 0.52
ATG4B Q9Y4P1 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20560701 0.84 MEN1 (0.53) KMT2AMEN1MAPTALDH1A1HTT
SCHEMBL3299680 0.83 KMT2A (0.73) KMT2AMEN1MAPTALDH1A1HTT
SCHEMBL11596948 0.83 KMT2A (0.73) KMT2AMEN1MAPTALDH1A1HTT
SCHEMBL20560550 0.81 SLC2A1 (0.69) KMT2AMEN1MAPTALDH1A1HTT
SCHEMBL27860200 0.80 KMT2A (0.80) KMT2AMEN1MAPTALDH1A1HTT
SCHEMBL20560730 0.79 MEN1 (0.49) KMT2AMEN1MAPTALDH1A1HTT
SCHEMBL20560226 0.79 MEN1 (0.49) KMT2AMEN1MAPTALDH1A1HTT
SCHEMBL28796269 0.79 KMT2A (0.67) KMT2AMEN1MAPTALDH1A1HTT
SCHEMBL6815023 0.78 KMT2A (0.81) KMT2AMEN1MAPTALDH1A1HTT
SCHEMBL14261340 0.78 NPC1 (0.68) KMT2AMEN1MAPTALDH1A1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108698982-B Fluorine atom-containing compound and use thereof 日产化学工业株式会社 2021-07-16 CN disclosed
EP-3404017-B1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF NISSAN CHEMICAL IND LTD (JP) 2020-05-13 EP disclosed
US-10336686-B2 Fluorine atom-containing compound and use thereof NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2019-07-02 US disclosed
US-20190031600-A1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2019-01-31 US disclosed
EP-3404017-A1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF Nissan Chemical Industries, Ltd. (JP) 2018-11-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10336686-B2 Fluorine atom-containing compound and use thereof ARF1, ARF5, ARFGAP1 KMT2A 1622/4885MEN1 755/4885MAPT 3103/4885
US-20190031600-A1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF ARF1, ARF5, ARFGAP1 KMT2A 1622/4885MEN1 755/4885MAPT 3103/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.