Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | RBBP5 | Q15291 | 5/20 | 0.57 |
| ▸ | DPY30 | Q9C005 | 5/20 | 0.57 |
| ▸ | ASH2L | Q9UBL3 | 5/20 | 0.57 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 5/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | FURIN | P09958 | 1/20 | 0.33 |
| ▸ | KRAS | P01116 | 2/20 | 0.32 |
| ▸ | MDM4 | O15151 | 4/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.32 |
| ▸ | MC4R | P32245 | 1/20 | 0.32 |
| ▸ | MC5R | P33032 | 1/20 | 0.32 |
| ▸ | MC3R | P41968 | 1/20 | 0.32 |
| ▸ | MC1R | Q01726 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclopropane SCHEMBL23295871 | 0.95 | WDR5 (0.55) | WDR5KMT2ARBBP5DPY30ASH2L | |
| SCHEMBL20564859 | 0.95 | WDR5 (0.55) | WDR5KMT2ARBBP5DPY30ASH2L | |
| SCHEMBL20565127 | 0.94 | WDR5 (0.54) | WDR5KMT2ARBBP5DPY30ASH2L | |
| SCHEMBL20564755 | 0.93 | WDR5 (0.53) | WDR5KMT2ARBBP5DPY30ASH2L | |
| SCHEMBL20565002 | 0.92 | WDR5 (0.54) | WDR5KMT2ARBBP5DPY30ASH2L | |
| SCHEMBL15005648 | 0.91 | WDR5 (0.65) | WDR5KMT2ARBBP5DPY30ASH2L | |
| SCHEMBL15004662 | 0.91 | WDR5 (0.65) | WDR5KMT2ARBBP5DPY30ASH2L | |
| SCHEMBL15004655 | 0.91 | WDR5 (0.65) | WDR5KMT2ARBBP5DPY30ASH2L | |
| SCHEMBL15004660 | 0.91 | WDR5 (0.65) | WDR5KMT2ARBBP5DPY30ASH2L | |
| SCHEMBL15004663 | 0.91 | WDR5 (0.65) | WDR5KMT2ARBBP5DPY30ASH2L |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210130401-A1 | PEPTIDOMIMETIC INHIBITORS OF THE WDR5-MLL INTERACTION | UNIV MICHIGAN REGENTS (US) | 2021-05-06 | — | — | US | claimed |
| WO-2018213228-A1 | PEPTIDOMIMETIC INHIBITORS OF THE WDR5-MLL INTERACTION | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2018-11-22 | — | — | WO | claimed |
| US-20210130401-A1 | PEPTIDOMIMETIC INHIBITORS OF THE WDR5-MLL INTERACTION | UNIV MICHIGAN REGENTS (US) | 2021-05-06 | — | — | US | disclosed |
| US-20210130401-A1 | PEPTIDOMIMETIC INHIBITORS OF THE WDR5-MLL INTERACTION | UNIV MICHIGAN REGENTS (US) | 2021-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210130401-A1 | PEPTIDOMIMETIC INHIBITORS OF THE WDR5-MLL INTERACTION | WDR5, MLLT1, WDR1 | WDR5 1/4885KMT2A 22/4885RBBP5 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.