SCHEMBL2056599

SCHEMBL2056599

CN(C)[C@H]1CCc2ccc(Nc3nc(N)n(-c4cc5c(nn4)-c4ccccc4CCC5)n3)cc2CC1

nearest known ligand 0.77

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
AXL P30530 15/20 0.77
FLT3 P36888 6/20 0.77
KIT P10721 3/20 0.77
AURKA O14965 2/20 0.77
EGFR P00533 1/20 0.77
RET P07949 1/20 0.77
MET P08581 1/20 0.77
SRC P12931 1/20 0.77
PDGFRA P16234 1/20 0.77
KDR P35968 1/20 0.77
TYRO3 Q06418 1/20 0.77
DDR1 Q08345 1/20 0.77
MERTK Q12866 1/20 0.77
AURKB Q96GD4 1/20 0.77
ALK Q9UM73 1/20 0.77
JAK2 O60674 1/20 0.37
IRAK4 Q9NWZ3 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30121445 1.00 AXL (0.77) AXLFLT3KITAURKAEGFR
SCHEMBL467995 1.00 AXL (0.77) AXLFLT3KITAURKAEGFR
SCHEMBL30121573 0.91 AXL (0.73) AXLFLT3KITAURKAEGFR
SCHEMBL1638518 0.91 AXL (0.73) AXLFLT3KITAURKAEGFR
SCHEMBL2056499 0.91 AXL (0.73) AXLFLT3KITAURKAEGFR
SCHEMBL30090865 0.91 AXL (0.73) AXLFLT3KITAURKAEGFR
SCHEMBL1639408 0.91 AXL (0.80) AXLFLT3KITAURKAEGFR
SCHEMBL30090884 0.91 AXL (0.80) AXLFLT3KITAURKAEGFR
SCHEMBL30090894 0.91 AXL (0.64) AXLFLT3KITAURKAEGFR
SCHEMBL2056528 0.91 AXL (0.64) AXLFLT3KITAURKAEGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230372337-A1 Combination Therapy Comprising an AXL Inhibitor BERGENBIO ASA (NO) 2023-11-23 US claimed
US-20230250169-A1 AXL Inhibitors for Antiviral Therapy BERGENBIO ASA (NO) 2023-08-10 US claimed
US-20230151100-A1 Method of Selecting Patients for Treatment with a Combination of an AXL Inhibitor and an Immune Checkpoint Modulator BERGENBIO ASA (NO) 2023-05-18 US claimed
EP-4138823-A1 METHOD OF SELECTING PATIENTS FOR TREATMENT WITH A COMBINATION OF AN AXL INHIBITOR AND AN IMMUNE CHECKPOINT MODULATOR BerGenBio ASA (NO) 2023-03-01 EP claimed
US-11534440-B2 Combination therapy with Axl inhibitor and immune checkpoint modulator or oncolytic virus BERGENBIO ASA (NO) 2022-12-27 US claimed
WO-2021214492-A1 METHOD OF SELECTING PATIENTS FOR TREATMENT WITH A COMBINATION OF AN AXL INHIBITOR AND AN IMMUNE CHECKPOINT MODULATOR BERGENBIO ASA (NO) 2021-10-28 WO claimed
EP-3804723-A1 COMBINATION THERAPY BerGenBio ASA (NO) 2021-04-14 EP claimed
WO-2021032883-A1 COMBINATION THERAPY OF A PATIENT SUBGROUP BERGENBIO ASA (NO) 2021-02-25 WO claimed
US-20190336500-A1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER RIGEL PHARMACEUTICALS, INC. 2019-11-07 US claimed
US-20180153888-A1 COMBINATION THERAPY WITH AXL INHIBITOR AND IMMUNE CHECKPOINT MODULATOR OR ONCOLYTIC VIRUS BERGENBIO ASA (NO) 2018-06-07 US claimed
US-20160339021-A1 USE OF KINASE INHIBTORS BERGENBIO ASA (NO) 2016-11-24 US claimed
EP-3076966-A2 USE OF KINASE INHIBITORS BerGenBio AS (NO) 2016-10-12 EP claimed
US-9079898-B2 Polycyclic heteroaryl substituted triazoles useful as Axl inhibitors RIGEL PHARMACEUTICALS, INC. (US) 2015-07-14 US claimed
WO-2015082887-A2 USE OF KINASE INHIBITORS BERGENBIO AS (NO) 2015-06-11 WO claimed
EP-2387395-B1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER RIGEL PHARMACEUTICALS INC (US) 2014-10-15 EP claimed
EP-2326641-B1 POLYCYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS RIGEL PHARMACEUTICALS INC (US) 2014-09-03 EP claimed
US-20130338161-A1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER RIGEL PHARMACEUTICALS INC (US) 2013-12-19 US claimed
US-8349838-B2 Polycyclic heteroaryl substituted triazoles useful as Axl inhibitors RIGEL PHARMACEUTICALS, INC. (US) 2013-01-08 US claimed
US-20110105511-A1 POLYCYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS RIGEL PHARMACEUTICALS, INC. (US) 2011-05-05 US claimed
US-20100196511-A1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER RIGEL PHARMACEUTICALS, INC. (US) 2010-08-05 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100196511-A1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER AXL, FLT3, MET AXL 1/4885FLT3 2/4885KIT 444/4885
US-20190336500-A1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER AXL, FLT3, MET AXL 1/4885FLT3 2/4885KIT 444/4885
US-11534440-B2 Combination therapy with Axl inhibitor and immune checkpoint modulator or oncolytic virus AXL, CD274, HAVCR2 AXL 1/4885FLT3 33/4885KIT 2345/4885
US-20230372337-A1 Combination Therapy Comprising an AXL Inhibitor AXL, CD274, CD47 AXL 1/4885FLT3 28/4885KIT 2025/4885
US-20230250169-A1 AXL Inhibitors for Antiviral Therapy FLT3, AXL, SARS1 AXL 2/4885FLT3 1/4885KIT 1463/4885
US-20160339021-A1 USE OF KINASE INHIBTORS INHA, ERBB2, MAP3K1 AXL 7/4885FLT3 28/4885KIT 227/4885
US-20230151100-A1 Method of Selecting Patients for Treatment with a Combination of an AXL Inhibitor and an Immune Checkpoint Modulator STK11, MERTK, AXL AXL 3/4885FLT3 33/4885KIT 890/4885
US-20110105511-A1 POLYCYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS AXL, TYRO3, ERBB3 AXL 1/4885FLT3 5/4885KIT 362/4885
US-20130338161-A1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER AXL, FLT3, MET AXL 1/4885FLT3 2/4885KIT 444/4885
US-20180153888-A1 COMBINATION THERAPY WITH AXL INHIBITOR AND IMMUNE CHECKPOINT MODULATOR OR ONCOLYTIC VIRUS AXL, CD274, HAVCR2 AXL 1/4885FLT3 33/4885KIT 2345/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.