Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | BRD2 | P25440 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 2/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
| ▸ | ACACA | Q13085 | 1/20 | 0.30 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1299428 | 0.91 | GRIN1 (0.35) | GRIN1GRIN2ALTA4HRIPK1ITGB3 | |
| SCHEMBL16190002 | 0.81 | GRIN1 (0.42) | GRIN1GRIN2ALTA4HRIPK1BRD4 | |
| SCHEMBL10186804 | 0.80 | CHRM2 (0.44) | GRIN1GRIN2ALTA4HBRD4BRD2 | |
| SCHEMBL20569460 | 0.79 | HRH3 (0.46) | TSHRUSP2DDB1CRBN | |
| SCHEMBL25738952 | 0.77 | GRIN1 (0.40) | GRIN1GRIN2ALTA4HBRD4BRD2 | |
| SCHEMBL13460109 | 0.77 | GRIN1 (0.40) | GRIN1GRIN2ALTA4HBRD4BRD2 | |
| SCHEMBL27256625 | 0.77 | CYP1A2 (0.43) | TSHRALDH1A1USP2CYP3A4CYP2C19 | |
| SCHEMBL27225506 | 0.76 | ITGB3 (0.37) | RIPK1TSHRITGB3ITGA2B | |
| SCHEMBL25476574 | 0.76 | CHRM2 (0.41) | GRIN1GRIN2ALTA4HBRD4BRD2 | |
| SCHEMBL26456980 | 0.75 | GRIN1 (0.42) | GRIN1GRIN2ALTA4HBRD4BRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3630749-A1 | 2-QUINOLONE DERIVED INHIBITORS OF BCL6 | Cancer Research Technology Limited (GB) | 2020-04-08 | — | — | EP | disclosed |
| WO-2018215798-A1 | 2-QUINOLONE DERIVED INHIBITORS OF BCL6 | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2018-11-29 | — | — | WO | disclosed |