Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.54 |
| ▸ | BRAF | P15056 | 6/20 | 0.49 |
| ▸ | FLT1 | P17948 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 3/20 | 0.45 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.45 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20568092 | 0.92 | RET (0.51) | KDRBRAFRETMAP3K7MAP4K2 | |
| SCHEMBL20568417 | 0.87 | MAP3K7 (0.56) | KDRBRAFKITRETMAP3K7 | |
| SCHEMBL20569399 | 0.85 | MAP3K7 (0.51) | KDRBRAFRETMAP3K7MAP4K2 | |
| SCHEMBL20568109 | 0.85 | RET (0.50) | KDRBRAFRETMAP3K7MAP4K2 | |
| SCHEMBL20568087 | 0.85 | KDR (0.48) | KDRBRAFRETMAP3K7MAP4K2 | |
| SCHEMBL20568823 | 0.85 | MAP3K7 (0.54) | KDRBRAFPDGFRBKITTEK | |
| SCHEMBL20569381 | 0.81 | KDR (0.48) | KDRBRAFRETMAP3K7MAP4K2 | |
| SCHEMBL20568408 | 0.81 | MAP4K2 (0.69) | BRAFPDGFRBKITMAP3K7MAP4K2 | |
| SCHEMBL20569635 | 0.80 | MAP3K7 (0.57) | KDRBRAFKITMAP3K7MAP4K2 | |
| SCHEMBL20570131 | 0.80 | MAP4K2 (0.59) | KDRBRAFKITRETMAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112601752-A | Novel inhibitors of MAP4K1 | 伊克诺斯科学公司 | 2021-04-02 | — | — | CN | claimed |
| EP-3630778-A1 | NOVEL INHIBITORS OF MAP4K1 | Ichnos Sciences SA (CH) | 2020-04-08 | — | — | EP | claimed |
| WO-2018215668-A1 | NOVEL INHIBITORS OF MAP4K1 | GLENMARK PHARMACEUTICALS S.A. (CH) | 2018-11-29 | — | — | WO | claimed |