Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 2/20 | 0.56 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | LYN | P07948 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 7/20 | 0.46 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.46 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 3/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HCK | P08631 | 1/20 | 0.42 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | LDLR | P01130 | 1/20 | 0.41 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20568823 | 0.92 | MAP3K7 (0.54) | MAP3K7MAP4K2CSF1RLYNKIT | |
| SCHEMBL20568092 | 0.92 | RET (0.51) | MAP3K7MAP4K2BRAFKDRRET | |
| SCHEMBL20568408 | 0.91 | MAP4K2 (0.69) | MAP3K7MAP4K2CSF1RLYNKIT | |
| SCHEMBL20570131 | 0.90 | MAP4K2 (0.59) | MAP3K7MAP4K2CSF1RLYNKIT | |
| SCHEMBL20569635 | 0.90 | MAP3K7 (0.57) | MAP3K7MAP4K2CSF1RLYNKIT | |
| SCHEMBL28555631 | 0.88 | MAP3K7 (0.56) | MAP3K7MAP4K2CSF1RLYNKIT | |
| SCHEMBL20568112 | 0.87 | KDR (0.54) | MAP3K7MAP4K2KITBRAFKDR | |
| SCHEMBL20569399 | 0.84 | MAP3K7 (0.51) | MAP3K7MAP4K2BRAFKDRRET | |
| SCHEMBL20568682 | 0.84 | MAP4K2 (0.60) | MAP3K7MAP4K2CSF1RKITBRAF | |
| SCHEMBL20568109 | 0.83 | RET (0.50) | MAP3K7MAP4K2BRAFKDRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112601752-A | Novel inhibitors of MAP4K1 | 伊克诺斯科学公司 | 2021-04-02 | — | — | CN | claimed |
| EP-3630778-A1 | NOVEL INHIBITORS OF MAP4K1 | Ichnos Sciences SA (CH) | 2020-04-08 | — | — | EP | claimed |
| WO-2018215668-A1 | NOVEL INHIBITORS OF MAP4K1 | GLENMARK PHARMACEUTICALS S.A. (CH) | 2018-11-29 | — | — | WO | claimed |