Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 3/20 | 0.50 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.50 |
| ▸ | BRAF | P15056 | 14/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | RAF1 | P04049 | 3/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20568729 | 0.95 | MAP4K2 (0.51) | MAP3K7MAP4K2BRAFKDRDDR1 | |
| SCHEMBL20568100 | 0.93 | MAP4K2 (0.59) | MAP3K7MAP4K2BRAFRAF1MAPK14 | |
| SCHEMBL20570131 | 0.93 | MAP4K2 (0.59) | MAP3K7MAP4K2BRAFKDRDDR1 | |
| SCHEMBL20568451 | 0.92 | MAP4K2 (0.48) | MAP3K7MAP4K2BRAFKDRDDR1 | |
| SCHEMBL20568292 | 0.92 | MAP4K2 (0.48) | MAP3K7MAP4K2BRAFKDR | |
| SCHEMBL20568121 | 0.92 | MAP4K2 (0.51) | MAP3K7MAP4K2BRAFKDRRAF1 | |
| SCHEMBL20568648 | 0.92 | MAP4K2 (0.51) | MAP3K7MAP4K2BRAFKDRDDR1 | |
| SCHEMBL20569506 | 0.91 | MAP4K2 (0.51) | MAP3K7MAP4K2BRAFKDRDDR1 | |
| SCHEMBL20569081 | 0.91 | MAP4K2 (0.50) | MAP3K7MAP4K2BRAFKDRDDR1 | |
| SCHEMBL20569397 | 0.91 | DDR2 (0.48) | MAP3K7MAP4K2KDRDDR1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112601752-A | Novel inhibitors of MAP4K1 | 伊克诺斯科学公司 | 2021-04-02 | — | — | CN | claimed |
| EP-3630778-A1 | NOVEL INHIBITORS OF MAP4K1 | Ichnos Sciences SA (CH) | 2020-04-08 | — | — | EP | claimed |
| WO-2018215668-A1 | NOVEL INHIBITORS OF MAP4K1 | GLENMARK PHARMACEUTICALS S.A. (CH) | 2018-11-29 | — | — | WO | claimed |