Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR2 | Q16832 | 13/20 | 0.48 |
| ▸ | DDR1 | Q08345 | 12/20 | 0.48 |
| ▸ | KIT | P10721 | 5/20 | 0.48 |
| ▸ | ABL1 | P00519 | 7/20 | 0.44 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.44 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.44 |
| ▸ | FES | P07332 | 1/20 | 0.44 |
| ▸ | FER | P16591 | 1/20 | 0.44 |
| ▸ | BCR | P11274 | 3/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20569030 | 0.93 | DDR2 (0.52) | DDR2DDR1KITABL1MAP3K7 | |
| SCHEMBL20568684 | 0.91 | MAP3K7 (0.50) | DDR1MAP3K7MAP4K2MAPK14MAP3K20 | |
| SCHEMBL20568102 | 0.90 | MAP3K7 (0.44) | MAP3K7MAP4K2MAPK14MAP3K20FES | |
| SCHEMBL20568750 | 0.89 | DDR1 (0.50) | DDR2DDR1KITABL1BCR | |
| SCHEMBL20568362 | 0.89 | DDR1 (0.50) | DDR2DDR1KITABL1BCR | |
| SCHEMBL20568363 | 0.89 | DDR1 (0.50) | DDR2DDR1KITABL1BCR | |
| SCHEMBL20569406 | 0.88 | DDR1 (0.43) | DDR2DDR1KITABL1MAP3K7 | |
| SCHEMBL20569243 | 0.87 | RET (0.44) | MAP3K7MAP4K2MAPK14KDR | |
| SCHEMBL20568477 | 0.87 | MAP3K7 (0.60) | ABL1MAP3K7MAP4K2MAPK14MAP3K20 | |
| SCHEMBL20568492 | 0.85 | RET (0.45) | KITMAP3K7MAP4K2KDRCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112601752-A | Novel inhibitors of MAP4K1 | 伊克诺斯科学公司 | 2021-04-02 | — | — | CN | claimed |
| EP-3630778-A1 | NOVEL INHIBITORS OF MAP4K1 | Ichnos Sciences SA (CH) | 2020-04-08 | — | — | EP | claimed |
| WO-2018215668-A1 | NOVEL INHIBITORS OF MAP4K1 | GLENMARK PHARMACEUTICALS S.A. (CH) | 2018-11-29 | — | — | WO | claimed |