SCHEMBL20568751

SCHEMBL20568751

Cc1ccc(S(=O)(=O)OCCC(C)(O)C(F)(F)F)cc1

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.44
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
STAT3 P40763 2/20 0.39
CA12 O43570 1/20 0.38
CA1 P00915 1/20 0.38
CA9 Q16790 1/20 0.38
RORC P51449 1/20 0.38
PSMD10 O75832 1/20 0.38
NPSR1 Q6W5P4 2/20 0.36
MAPT P10636 1/20 0.36
CYP2D6 P10635 1/20 0.35
GAA P10253 1/20 0.35
CTDSP1 Q9GZU7 1/20 0.35
SIRT5 Q9NXA8 1/20 0.35
CA2 P00918 1/20 0.35
HSD11B1 P28845 1/20 0.35
KEAP1 Q14145 1/20 0.35
NFE2L2 Q16236 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25266316 0.92 STAT3 (0.40) ALDH1A1MEN1KMT2ASTAT3CA12
SCHEMBL4128235 0.87 ALDH1A1 (0.41) ALDH1A1MEN1KMT2ASTAT3CA12
SCHEMBL14460714 0.85 ALDH1A1 (0.46) ALDH1A1MEN1KMT2ASTAT3CA1
SCHEMBL29658223 0.85 ALDH1A1 (0.46) ALDH1A1MEN1KMT2ASTAT3CA1
SCHEMBL30156542 0.85 ALDH1A1 (0.46) ALDH1A1MEN1KMT2ASTAT3CA1
SCHEMBL23779385 0.84 CA12 (0.41) ALDH1A1MEN1KMT2ASTAT3CA12
SCHEMBL1438581 0.84 ALDH1A1 (0.49) ALDH1A1MEN1KMT2ASTAT3CA12
SCHEMBL21618125 0.84 ALDH1A1 (0.53) ALDH1A1MEN1KMT2ASTAT3CA12
SCHEMBL25206087 0.84 KMT2A (0.36) ALDH1A1MEN1KMT2ASTAT3CA12
SCHEMBL9995667 0.83 CA12 (0.40) ALDH1A1MEN1KMT2ASTAT3CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4565228-A2 COMPOSITIONS AND METHODS FOR INDUCING FERROPTOSIS Kojin Therapeutics, Inc. (US) 2025-06-11 EP disclosed
US-20240417388-A1 BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6 CANCER RESEARCH TECH LTD (GB) 2024-12-19 US disclosed
US-12110286-B2 Benzimidazolone derived inhibitors of BCL6 CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2024-10-08 US disclosed
EP-4374858-A2 BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6 Cancer Research Technology Limited (GB) 2024-05-29 EP disclosed
EP-3630291-B9 BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6 CANCER RESEARCH TECH LTD (GB) 2024-05-29 EP disclosed
WO-2024030960-A2 COMPOSITIONS AND METHODS FOR INDUCING FERROPTOSIS Kojin Therapeutics, Inc. (US) 2024-02-08 WO disclosed
EP-3630291-B1 BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6 CANCER RESEARCH TECH LTD (GB) 2024-01-10 EP disclosed
US-20210147382-A1 BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6 CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2021-05-20 US disclosed
US-20210147382-A1 BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6 CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2021-05-20 US disclosed
EP-3630291-A1 BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6 Cancer Research Technology Limited (GB) 2020-04-08 EP disclosed
WO-2018215801-A1 BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6 CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2018-11-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210147382-A1 BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6 BCL6, BCL6B, BCL3 ALDH1A1 1654/4885MEN1 727/4885KMT2A 752/4885
US-20240417388-A1 BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6 BCL6, BCL6B, BCL3 ALDH1A1 1654/4885MEN1 727/4885KMT2A 752/4885
US-12110286-B2 Benzimidazolone derived inhibitors of BCL6 BCL6, BCL6B, BCL3 ALDH1A1 1654/4885MEN1 727/4885KMT2A 752/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.