Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL6 | P41182 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | SCN7A | Q01118 | 2/20 | 0.39 |
| ▸ | PARG | Q86W56 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HBB | P68871 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20568631 | 0.84 | BCL6 (0.55) | BCL6SIGMAR1KMT2AKDM4EMEN1 | |
| SCHEMBL20569580 | 0.80 | BRPF1 (0.47) | BCL6KMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL20568379 | 0.77 | CNR1 (0.43) | BCL6PARGKMT2AKDM4EMEN1 | |
| SCHEMBL25724477 | 0.74 | PARG (0.59) | SIGMAR1ADRA2AADRA2BADRA2CHRH1 | |
| SCHEMBL25724540 | 0.73 | PARG (0.49) | SIGMAR1ADRA2AADRA2BADRA2CHRH1 | |
| SCHEMBL2075865 | 0.72 | KMT2A (0.47) | KMT2AKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL25724546 | 0.71 | PARG (0.48) | SIGMAR1ADRA2AADRA2BADRA2CHRH1 | |
| SCHEMBL23610837 | 0.70 | BCL6 (0.47) | BCL6KMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL25724544 | 0.69 | PARG (0.46) | SIGMAR1ADRA2AADRA2BADRA2CHRH1 | |
| SCHEMBL25439300 | 0.69 | PARG (0.46) | PARGKMT2AKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3630749-A1 | 2-QUINOLONE DERIVED INHIBITORS OF BCL6 | Cancer Research Technology Limited (GB) | 2020-04-08 | — | — | EP | disclosed |
| WO-2018215798-A1 | 2-QUINOLONE DERIVED INHIBITORS OF BCL6 | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2018-11-29 | — | — | WO | disclosed |