Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.43 |
| ▸ | MC5R | P33032 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25491087 | 0.87 | FAAH (0.44) | FAAHKDM4EMEN1KMT2AATM | |
| SCHEMBL2778173 | 0.86 | FAAH (0.53) | FAAHKDM4EMEN1KMT2AATM | |
| SCHEMBL20567707 | 0.85 | FAAH (0.46) | FAAHL3MBTL1 | |
| SCHEMBL20567143 | 0.85 | CHRM3 (0.51) | FAAHMEN1KMT2ATDP1SIGMAR1 | |
| SCHEMBL2312576 | 0.84 | FAAH (0.54) | FAAHKDM4EMEN1KMT2AATM | |
| SCHEMBL20570843 | 0.84 | FAAH (0.52) | FAAHKDM4EMEN1KMT2AATM | |
| SCHEMBL20566586 | 0.82 | FAAH (0.59) | FAAH | |
| SCHEMBL20571160 | 0.81 | FAAH (0.49) | FAAHKDM4EMEN1KMT2AATM | |
| SCHEMBL20570037 | 0.81 | FAAH (0.50) | FAAHKDM4EMEN1KMT2AATM | |
| SCHEMBL2931107 | 0.80 | KMT2A (0.53) | FAAHKDM4EMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3634404-A1 | PYRAZOLE MAGL INHIBITORS | Lundbeck La Jolla Research Center, Inc. (US) | 2020-04-15 | — | — | EP | disclosed |
| EP-3630744-A1 | PYRAZOLE MAGL INHIBITORS | Lundbeck La Jolla Research Center, Inc. (US) | 2020-04-08 | — | — | EP | disclosed |
| WO-2018217809-A1 | PYRAZOLE MAGL INHIBITORS | ABIDE THERAPEUTICS, INC. (US) | 2018-11-29 | — | — | WO | disclosed |
| WO-2018217805-A1 | PYRAZOLE MAGL INHIBITORS | ABIDE THERAPEUTICS, INC. (US) | 2018-11-29 | — | — | WO | disclosed |