Sugi Predict

Sugi Predict / Compounds / SCHEMBL20570210

SCHEMBL20570210

SCHEMBL20570210

COC(=O)C1(Oc2cc(Cl)ccc2CN2CCN(C(=O)OC(C)(C)C)CC2)CC1

nearest known ligand 0.49

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ VEGFA P15692 1/20 0.49
▸ EGLN1 Q9GZT9 1/20 0.49
▸ MGLL Q99685 8/20 0.46
▸ SETD7 Q8WTS6 1/20 0.46
▸ ABHD6 Q9BV23 4/20 0.43
▸ PLA2G7 Q13093 3/20 0.43
▸ MEN1 O00255 2/20 0.43
▸ KMT2A Q03164 2/20 0.43
▸ STS P08842 1/20 0.42
▸ DDR1 Q08345 2/20 0.41
▸ CNR1 P21554 1/20 0.41
▸ DRD2 P14416 1/20 0.41
▸ DRD4 P21917 1/20 0.41
▸ LMNA P02545 1/20 0.40
▸ TP53 P04637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30459413 0.90 MGLL (0.55) VEGFAEGLN1MGLLSETD7ABHD6
SCHEMBL20570500 0.90 MGLL (0.55) VEGFAEGLN1MGLLSETD7ABHD6
SCHEMBL20151863 0.89 MGLL (0.48) VEGFAEGLN1MGLLSETD7MEN1
SCHEMBL20570220 0.88 MGLL (0.47) MGLLABHD6PLA2G7MEN1KMT2A
SCHEMBL20137114 0.87 MGLL (0.61) MGLLABHD6PLA2G7MEN1KMT2A
SCHEMBL21896336 0.85 KCNH2 (0.42) MGLLMEN1KMT2ADRD2DRD4
SCHEMBL15093856 0.80 VEGFA (0.57) VEGFAEGLN1MGLLSETD7ABHD6
SCHEMBL17513187 0.80 VEGFA (0.59) VEGFAEGLN1MGLLSETD7ABHD6
SCHEMBL20137035 0.80 MGLL (0.59) VEGFAEGLN1MGLLSETD7ABHD6
SCHEMBL15263897 0.79 VEGFA (0.54) VEGFAEGLN1MGLLSETD7ABHD6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3634404-B1 PYRAZOLE MAGL INHIBITORS H LUNDBECK AS (DK) 2024-11-20 — — EP disclosed
CN-110678177-B Pyrazole MAGL inhibitors H.隆德贝克有限公司 2023-06-13 — — CN disclosed
US-11149037-B2 Pyrazole MAGL inhibitors H. LUNDBECK A/S (DK) 2021-10-19 — — US disclosed
US-11149037-B2 Pyrazole MAGL inhibitors H. LUNDBECK A/S (DK) 2021-10-19 — — US disclosed
EP-3634404-A1 PYRAZOLE MAGL INHIBITORS Lundbeck La Jolla Research Center, Inc. (US) 2020-04-15 — — EP disclosed
US-20200087304-A1 PYRAZOLE MAGL INHIBITORS H. LUNDBECK A/S (DK) 2020-03-19 — — US disclosed
US-20200087304-A1 PYRAZOLE MAGL INHIBITORS H. LUNDBECK A/S (DK) 2020-03-19 — — US disclosed
CN-110678177-A Pyrazole MAGL inhibitors 隆德贝克拉荷亚研究中心有限公司 2020-01-10 — — CN disclosed
WO-2018217809-A1 PYRAZOLE MAGL INHIBITORS ABIDE THERAPEUTICS, INC. (US) 2018-11-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11149037-B2 Pyrazole MAGL inhibitors MAGI3, MAG, PYM1 VEGFA 4884/4885EGLN1 2785/4885MGLL 4/4885
US-20200087304-A1 PYRAZOLE MAGL INHIBITORS MAGI3, MAG, PYM1 VEGFA 4884/4885EGLN1 2785/4885MGLL 4/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.