Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR5 | Q9H228 | 15/20 | 0.66 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | HTR1D | P28221 | 1/20 | 0.52 |
| ▸ | HTR1B | P28222 | 1/20 | 0.52 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20679833 | 1.00 | S1PR5 (0.66) | S1PR5HTR1AHTR1DHTR1BS1PR1 | |
| SCHEMBL20573464 | 1.00 | S1PR5 (0.66) | S1PR5HTR1AHTR1DHTR1BS1PR1 | |
| SCHEMBL19201141 | 1.00 | S1PR5 (0.66) | S1PR5HTR1AHTR1DHTR1BS1PR1 | |
| SCHEMBL20573219 | 1.00 | S1PR5 (0.66) | S1PR5HTR1AHTR1DHTR1BS1PR1 | |
| SCHEMBL20573452 | 1.00 | S1PR5 (0.66) | S1PR5HTR1AHTR1DHTR1BS1PR1 | |
| SCHEMBL29332508 | 0.90 | S1PR5 (0.53) | S1PR5HTR1AHTR1DHTR1B | |
| SCHEMBL20573751 | 0.85 | S1PR5 (0.85) | S1PR5S1PR1S1PR3 | |
| SCHEMBL20679863 | 0.84 | S1PR5 (0.64) | S1PR5HTR1AHTR1DHTR1B | |
| SCHEMBL19201143 | 0.82 | S1PR5 (0.61) | S1PR5HTR1AHTR1DHTR1B | |
| SCHEMBL19201148 | 0.79 | S1PR5 (1.00) | S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3409658-B9 | TETRAHYDRONAPHTHALENE DERIVATIVE | ONO PHARMACEUTICAL CO (JP) | 2024-07-17 | — | — | EP | disclosed |
| EP-3409658-B1 | TETRAHYDRONAPHTHALENE DERIVATIVE | ONO PHARMACEUTICAL CO (JP) | 2024-03-06 | — | — | EP | disclosed |
| US-10730830-B2 | Tetrahydronaphthalene derivative | ONO PHARMACEUTICAL CO., LTD. (JP) | 2020-08-04 | — | — | US | disclosed |
| US-20190031605-A1 | TETRAHYDRONAPHTHALENE DERIVATIVE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2019-01-31 | — | — | US | disclosed |
| EP-3409658-A1 | TETRAHYDRONAPHTHALENE DERIVATIVE | ONO Pharmaceutical Co., Ltd. (JP) | 2018-12-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10730830-B2 | Tetrahydronaphthalene derivative | S1PR5, S1PR1, GPR55 | S1PR5 1/4885HTR1A 112/4885HTR1D 86/4885 |
| US-20190031605-A1 | TETRAHYDRONAPHTHALENE DERIVATIVE | S1PR5, S1PR1, GPR55 | S1PR5 1/4885HTR1A 79/4885HTR1D 77/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.