Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MPL | P40238 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3389669 | 0.97 | EPHX2 (0.40) | EPHX2NPC1RAB9ATSHRMCOLN3 | |
| SCHEMBL5802385 | 0.95 | EPHX2 (0.42) | EPHX2NPC1RAB9ATSHRMCOLN3 | |
| SCHEMBL6417418 | 0.88 | AKR1C3 (0.36) | EPHX2RAB9ATSHRGAAHTT | |
| SCHEMBL9485617 | 0.88 | PIK3CG (0.32) | EPHX2TSHRGAAHTTLMNA | |
| SCHEMBL963562 | 0.87 | NPC1 (0.42) | EPHX2NPC1RAB9ALMNACNR1 | |
| SCHEMBL23387579 | 0.86 | MRGPRX1 (0.33) | EPHX2RORCGAAHTTLMNA | |
| SCHEMBL7526268 | 0.86 | CYP2C9 (0.35) | EPHX2NPC1TSHRGAAPKM | |
| SCHEMBL15229660 | 0.86 | BRD4 (0.35) | EPHX2MEN1KMT2AMPLCNR1 | |
| SCHEMBL8945001 | 0.86 | CYP2C9 (0.35) | EPHX2NPC1TSHRGAAPKM | |
| SCHEMBL23151945 | 0.86 | FFAR4 (0.32) | EPHX2GAAHTTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3212641-B1 | THIAZOLES AS MODULATORS OF RORYT | JANSSEN PHARMACEUTICA NV (BE) | 2018-12-05 | — | — | EP | disclosed |