Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 11/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 11/20 | 0.47 |
| ▸ | SCN8A | Q9UQD0 | 11/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20575318 | 0.89 | HDAC6 (0.43) | SCN1ASCN5ASCN8ANR1I2SCN1B | |
| SCHEMBL22535811 | 0.89 | HDAC6 (0.43) | SCN1ASCN5ASCN8ANR1I2SCN1B | |
| SCHEMBL20575312 | 0.89 | HDAC6 (0.43) | SCN1ASCN5ASCN8ANR1I2SCN1B | |
| SCHEMBL22535675 | 0.86 | SCN1A (0.40) | SCN1ASCN5ASCN8ANR1I2CYP2C9 | |
| SCHEMBL20575147 | 0.81 | HTR7 (0.53) | NTRK1HTR7 | |
| SCHEMBL20575148 | 0.81 | HTR7 (0.53) | NTRK1HTR7 | |
| SCHEMBL20575173 | 0.78 | PRCP (0.42) | HTR7 | |
| SCHEMBL20575315 | 0.77 | SCN1A (0.39) | SCN1ASCN5ASCN8AHTR7 | |
| SCHEMBL21593091 | 0.72 | HTR7 (0.58) | HTR7 | |
| SCHEMBL4375461 | 0.72 | HTR7 (0.58) | HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10800760-B2 | Trk inhibition | NANTBIO, INC. (US) | 2020-10-13 | — | — | US | disclosed |
| US-10800760-B2 | Trk inhibition | NANTBIO, INC. (US) | 2020-10-13 | — | — | US | disclosed |
| US-20180346450-A1 | TRK INHIBITION | NANTBIO, INC. | 2018-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180346450-A1 | TRK INHIBITION | NTRK1, NTRK3, NTRK2 | SCN1A 1866/4885SCN5A 1721/4885SCN8A 2891/4885 |
| US-10800760-B2 | Trk inhibition | NTRK1, NTRK3, NTRK2 | SCN1A 1866/4885SCN5A 1721/4885SCN8A 2891/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.