Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23578345 | 0.94 | TAAR1 (0.45) | TAAR1HTR2AHMOX1SIGMAR1PTPN2 | |
| SCHEMBL11103061 | 0.86 | TAAR1 (0.50) | TAAR1HTR2AIDO1NPC1SMN1; SMN2 | |
| SCHEMBL31124935 | 0.80 | TAAR1 (0.48) | TAAR1IDO1 | |
| SCHEMBL28134403 | 0.80 | ESR1 (0.56) | TAAR1SIGMAR1L3MBTL1 | |
| SCHEMBL4589012 | 0.78 | CYP1A2 (0.46) | TAAR1PTPN2PTPN1PTPN6PTPN11 | |
| SCHEMBL30024710 | 0.78 | PTPN2 (0.40) | PTPN2PTPN1PTPN6PTPN11HDAC1 | |
| SCHEMBL31124934 | 0.78 | TAAR1 (0.57) | TAAR1PTPN2PTPN1PTPN6PTPN11 | |
| SCHEMBL7904900 | 0.78 | TAAR1 (0.62) | TAAR1HTR2AHMOX1SIGMAR1IDO1 | |
| SCHEMBL5238701 | 0.78 | TAAR1 (0.62) | TAAR1HTR2AHMOX1SIGMAR1IDO1 | |
| SCHEMBL8082932 | 0.77 | FAAH (0.48) | HTR2ASIGMAR1IDO1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10246419-B2 | Liver X receptor (LXR) modulators | RALEXAR THERAPEUTICS, INC. (US) | 2019-04-02 | — | — | US | disclosed |
| US-20180346427-A1 | LIVER X RECEPTOR (LXR) MODULATORS | RALEXAR THERAPEUTICS, INC. | 2018-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10246419-B2 | Liver X receptor (LXR) modulators | NR1H2, NR1H3, NR1H4 | TAAR1 640/4885HTR2A 2146/4885HMOX1 645/4885 |
| US-20180346427-A1 | LIVER X RECEPTOR (LXR) MODULATORS | NR1H2, NR1H3, NR1H4 | TAAR1 640/4885HTR2A 2146/4885HMOX1 645/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.