Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20575512 | 0.91 | CHRM5 (0.31) | CHRM5SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL20574742 | 0.89 | TGFBR1 (0.33) | CHRM5 | |
| SCHEMBL20575457 | 0.89 | TGFBR1 (0.33) | CHRM5 | |
| SCHEMBL20576406 | 0.87 | SLC6A2 (0.36) | CHRM5SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL20575481 | 0.86 | CHRM5 (0.32) | CHRM5 | |
| SCHEMBL20575560 | 0.86 | TGFBR1 (0.33) | CHRM5 | |
| SCHEMBL20575459 | 0.85 | SLC6A2 (0.33) | CHRM5SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL20575487 | 0.85 | SLC6A2 (0.35) | CHRM5SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL20575555 | 0.85 | SLC6A2 (0.31) | CHRM5SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL20575349 | 0.83 | CHRM5 (0.36) | CHRM5SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180346487-A1 | Fused Imidazole Derivatives as TGF-Beta Inhibitors | MIDCAP FINANCIAL TRUST | 2018-12-06 | — | — | US | claimed |
| US-10696693-B2 | Fused imidazole derivatives as TGF-beta inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2020-06-30 | — | — | US | disclosed |
| US-20180346487-A1 | Fused Imidazole Derivatives as TGF-Beta Inhibitors | MIDCAP FINANCIAL TRUST | 2018-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10696693-B2 | Fused imidazole derivatives as TGF-beta inhibitors | TGFBR1, TGFBR2, SMAD3 | CHRM5 1140/4885SLC6A2 3506/4885SLC6A4 3203/4885 |
| US-20180346487-A1 | Fused Imidazole Derivatives as TGF-Beta Inhibitors | TGFBR1, TGFBR2, SMAD3 | CHRM5 1140/4885SLC6A2 3506/4885SLC6A4 3203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.