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SCHEMBL20576083

SCHEMBL20576083

CCc1cc(Cl)nnc1NS(=O)(=O)c1ccccc1Cl

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 2/20 0.46
▸ LMNA P02545 2/20 0.46
▸ EDNRA P25101 3/20 0.46
▸ CCR4 P51679 1/20 0.44
▸ HTT P42858 1/20 0.44
▸ PKM P14618 1/20 0.43
▸ MEN1 O00255 1/20 0.43
▸ KMT2A Q03164 1/20 0.43
▸ EDNRB P24530 1/20 0.42
▸ MAPT P10636 1/20 0.42
▸ SLC22A12 Q96S37 2/20 0.41
▸ ALDH1A1 P00352 1/20 0.41
▸ MCL1 Q07820 1/20 0.41
▸ BRD4 O60885 1/20 0.41
▸ PTGDR2 Q9Y5Y4 2/20 0.41
▸ PGR P06401 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30634111 1.00 GAA (0.46) GAALMNAEDNRACCR4HTT
SCHEMBL28449129 0.81 CCR4 (0.44) EDNRACCR4
SCHEMBL30634075 0.81 CCR4 (0.44) EDNRACCR4
SCHEMBL30634069 0.76 GAA (0.49) GAALMNAEDNRAHTTPKM
SCHEMBL20576018 0.76 GAA (0.49) GAALMNAEDNRAHTTPKM
SCHEMBL13853039 0.73 SLC22A12 (0.64) GAALMNAMEN1KMT2ASLC22A12
SCHEMBL13629320 0.71 SLC22A12 (0.54) GAALMNAMEN1KMT2AMAPT
SCHEMBL13629338 0.70 SLC22A12 (0.53) GAALMNAMEN1KMT2ASLC22A12
SCHEMBL5735882 0.70 CCR4 (0.51) CCR4
SCHEMBL22034320 0.70 CCR4 (0.47) GAALMNAEDNRACCR4MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12479818-B2 Treatment of fibrosis with IRE1 small molecule inhibitors CORNELL UNIVERSITY (US) 2025-11-25 — — US disclosed
EP-3707126-B1 IRE1 SMALL MOLECULE INHIBITORS UNIV CORNELL (US) 2025-05-14 — — EP disclosed
US-20240425477-A1 IRE1 SMALL MOLECULE INHIBITORS CORNELL UNIVERSITY 2024-12-26 — — US disclosed
US-12071424-B2 IRE1 small molecule inhibitors CORNELL UNIVERSITY (US) 2024-08-27 — — US disclosed
CN-111566089-B IRE1 small molecule inhibitors 康奈尔大学 2023-11-17 — — CN disclosed
US-20230271935-A1 IRE1 SMALL MOLECULE INHIBITORS CORNELL UNIVERSITY 2023-08-31 — — US disclosed
US-20230271935-A1 IRE1 SMALL MOLECULE INHIBITORS CORNELL UNIVERSITY 2023-08-31 — — US disclosed
US-20230271935-A1 IRE1 SMALL MOLECULE INHIBITORS CORNELL UNIVERSITY 2023-08-31 — — US disclosed
US-11649224-B2 IRE1 small molecule inhibitors CORNELL UNIVERSITY (US) 2023-05-16 — — US disclosed
US-11649224-B2 IRE1 small molecule inhibitors CORNELL UNIVERSITY (US) 2023-05-16 — — US disclosed
CN-111566089-A IRE1 small molecule inhibitor 康奈尔大学 2020-08-21 — — CN disclosed
US-10745379-B2 IRE1 small molecule inhibitors CORNELL UNIVERSITY (US) 2020-08-18 — — US disclosed
US-10745379-B2 IRE1 small molecule inhibitors CORNELL UNIVERSITY (US) 2020-08-18 — — US disclosed
US-20200157079-A1 IRE1 Small Molecule Inhibitors QUENTIS THERAPEUTICS, INC. (US) 2020-05-21 — — US disclosed
US-20200157079-A1 IRE1 Small Molecule Inhibitors QUENTIS THERAPEUTICS, INC. (US) 2020-05-21 — — US disclosed
EP-3630748-A1 IRE1 SMALL MOLECULE INHIBITORS Quentis Therapeutics, Inc. (US) 2020-04-08 — — EP disclosed
US-20190169160-A1 IRE1 SMALL MOLECULE INHIBITORS CORNELL UNIVERSITY 2019-06-06 — — US disclosed
US-20190169160-A1 IRE1 SMALL MOLECULE INHIBITORS CORNELL UNIVERSITY 2019-06-06 — — US disclosed
WO-2018222918-A1 IRE1 SMALL MOLECULE INHIBITORS QUENTIS THERAPEUTICS, INC. (US) 2018-12-06 — — WO disclosed
US-20180346446-A1 IRE1 SMALL MOLECULE INHIBITORS CORNELL UNIVERSITY 2018-12-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230271935-A1 IRE1 SMALL MOLECULE INHIBITORS XBP1, ERN2, ERN1 GAA 1747/4885LMNA 2127/4885EDNRA 2093/4885
US-20240425477-A1 IRE1 SMALL MOLECULE INHIBITORS XBP1, ERN2, ERN1 GAA 1747/4885LMNA 2127/4885EDNRA 2093/4885
US-20200157079-A1 IRE1 Small Molecule Inhibitors XBP1, ERN2, ERN1 GAA 1747/4885LMNA 2127/4885EDNRA 2093/4885
US-12071424-B2 IRE1 small molecule inhibitors XBP1, ERN2, ERN1 GAA 1747/4885LMNA 2127/4885EDNRA 2093/4885
US-12479818-B2 Treatment of fibrosis with IRE1 small molecule inhibitors XBP1, DDIT3, HSP90B1 GAA 2332/4885LMNA 1598/4885EDNRA 437/4885
US-11649224-B2 IRE1 small molecule inhibitors XBP1, ERN2, ERN1 GAA 1747/4885LMNA 2127/4885EDNRA 2093/4885
US-20180346446-A1 IRE1 SMALL MOLECULE INHIBITORS XBP1, ERN2, ERN1 GAA 1747/4885LMNA 2127/4885EDNRA 2093/4885
US-20190169160-A1 IRE1 SMALL MOLECULE INHIBITORS XBP1, ERN2, ERN1 GAA 1747/4885LMNA 2127/4885EDNRA 2093/4885
US-10745379-B2 IRE1 small molecule inhibitors XBP1, ERN2, ERN1 GAA 1747/4885LMNA 2127/4885EDNRA 2093/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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