Sugi Predict

Sugi Predict / Compounds / SCHEMBL20576018

SCHEMBL20576018

SCHEMBL20576018

CCc1cc(NS(=O)(=O)c2ccccc2Cl)nnc1Cl

nearest known ligand 0.49

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 3/20 0.49
▸ LMNA P02545 2/20 0.49
▸ PKM P14618 1/20 0.49
▸ EDNRA P25101 3/20 0.46
▸ EDNRB P24530 1/20 0.42
▸ HSD11B1 P28845 1/20 0.42
▸ MAPT P10636 1/20 0.42
▸ HTT P42858 1/20 0.41
▸ SLC22A12 Q96S37 2/20 0.41
▸ ALDH1A1 P00352 1/20 0.41
▸ MCL1 Q07820 1/20 0.41
▸ BRD4 O60885 1/20 0.41
▸ PGR P06401 1/20 0.41
▸ MEN1 O00255 1/20 0.41
▸ KMT2A Q03164 1/20 0.41
▸ TSHR P16473 1/20 0.40
▸ HSD17B10 Q99714 1/20 0.40
▸ SLC40A1 Q9NP59 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30634069 1.00 GAA (0.49) GAALMNAPKMEDNRAEDNRB
SCHEMBL21047994 0.80 BRD4 (0.50) GAALMNAPKMEDNRAEDNRB
SCHEMBL30634071 0.80 BRD4 (0.50) GAALMNAPKMEDNRAEDNRB
SCHEMBL20576083 0.76 GAA (0.46) GAALMNAPKMEDNRAEDNRB
SCHEMBL30634111 0.76 GAA (0.46) GAALMNAPKMEDNRAEDNRB
SCHEMBL13853039 0.73 SLC22A12 (0.64) GAALMNASLC22A12ALDH1A1BRD4
SCHEMBL21047976 0.72 PKM (0.58) GAALMNAPKMEDNRAEDNRB
SCHEMBL30634091 0.72 PKM (0.58) GAALMNAPKMEDNRAEDNRB
SCHEMBL22034323 0.71 PKM (0.57) GAALMNAPKMEDNRAEDNRB
SCHEMBL13629320 0.71 SLC22A12 (0.54) GAALMNAMAPTSLC22A12ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12479818-B2 Treatment of fibrosis with IRE1 small molecule inhibitors CORNELL UNIVERSITY (US) 2025-11-25 — — US disclosed
EP-3707126-B1 IRE1 SMALL MOLECULE INHIBITORS UNIV CORNELL (US) 2025-05-14 — — EP disclosed
US-20240425477-A1 IRE1 SMALL MOLECULE INHIBITORS CORNELL UNIVERSITY 2024-12-26 — — US disclosed
US-12071424-B2 IRE1 small molecule inhibitors CORNELL UNIVERSITY (US) 2024-08-27 — — US disclosed
CN-111566089-B IRE1 small molecule inhibitors 康奈尔大学 2023-11-17 — — CN disclosed
US-20230271935-A1 IRE1 SMALL MOLECULE INHIBITORS CORNELL UNIVERSITY 2023-08-31 — — US disclosed
US-20230271935-A1 IRE1 SMALL MOLECULE INHIBITORS CORNELL UNIVERSITY 2023-08-31 — — US disclosed
US-20230271935-A1 IRE1 SMALL MOLECULE INHIBITORS CORNELL UNIVERSITY 2023-08-31 — — US disclosed
US-11649224-B2 IRE1 small molecule inhibitors CORNELL UNIVERSITY (US) 2023-05-16 — — US disclosed
US-11649224-B2 IRE1 small molecule inhibitors CORNELL UNIVERSITY (US) 2023-05-16 — — US disclosed
WO-2020232401-A1 COMBINATION THERAPIES WITH IRE1 SMALL MOLECULE INHIBITORS CORNELL UNIVERSITY (US) 2020-11-19 — — WO disclosed
WO-2020232403-A1 TREATMENT OF FIBROSIS WITH IRE1 SMALL MOLECULE INHIBITORS CORNELL UNIVERSITY (US) 2020-11-19 — — WO disclosed
EP-3707126-A1 IRE1 SMALL MOLECULE INHIBITORS Cornell University (US) 2020-09-16 — — EP disclosed
CN-111566089-A IRE1 small molecule inhibitor 康奈尔大学 2020-08-21 — — CN disclosed
US-10745379-B2 IRE1 small molecule inhibitors CORNELL UNIVERSITY (US) 2020-08-18 — — US disclosed
US-20200157079-A1 IRE1 Small Molecule Inhibitors QUENTIS THERAPEUTICS, INC. (US) 2020-05-21 — — US disclosed
EP-3630748-A1 IRE1 SMALL MOLECULE INHIBITORS Quentis Therapeutics, Inc. (US) 2020-04-08 — — EP disclosed
US-20190169160-A1 IRE1 SMALL MOLECULE INHIBITORS CORNELL UNIVERSITY 2019-06-06 — — US disclosed
US-20180346446-A1 IRE1 SMALL MOLECULE INHIBITORS CORNELL UNIVERSITY 2018-12-06 — — US disclosed
WO-2018222918-A1 IRE1 SMALL MOLECULE INHIBITORS QUENTIS THERAPEUTICS, INC. (US) 2018-12-06 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230271935-A1 IRE1 SMALL MOLECULE INHIBITORS XBP1, ERN2, ERN1 GAA 1747/4885LMNA 2127/4885PKM 2987/4885
US-20240425477-A1 IRE1 SMALL MOLECULE INHIBITORS XBP1, ERN2, ERN1 GAA 1747/4885LMNA 2127/4885PKM 2987/4885
US-20200157079-A1 IRE1 Small Molecule Inhibitors XBP1, ERN2, ERN1 GAA 1747/4885LMNA 2127/4885PKM 2987/4885
US-12071424-B2 IRE1 small molecule inhibitors XBP1, ERN2, ERN1 GAA 1747/4885LMNA 2127/4885PKM 2987/4885
US-12479818-B2 Treatment of fibrosis with IRE1 small molecule inhibitors XBP1, DDIT3, HSP90B1 GAA 2332/4885LMNA 1598/4885PKM 3719/4885
US-11649224-B2 IRE1 small molecule inhibitors XBP1, ERN2, ERN1 GAA 1747/4885LMNA 2127/4885PKM 2987/4885
US-20180346446-A1 IRE1 SMALL MOLECULE INHIBITORS XBP1, ERN2, ERN1 GAA 1747/4885LMNA 2127/4885PKM 2987/4885
US-20190169160-A1 IRE1 SMALL MOLECULE INHIBITORS XBP1, ERN2, ERN1 GAA 1747/4885LMNA 2127/4885PKM 2987/4885
US-10745379-B2 IRE1 small molecule inhibitors XBP1, ERN2, ERN1 GAA 1747/4885LMNA 2127/4885PKM 2987/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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