Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | CASP2 | P42575 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17673062 | 0.87 | MAPT (0.65) | MEN1MAPTKMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL1736045 | 0.81 | MEN1 (0.46) | MEN1MAPTKMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL31241142 | 0.81 | SMN1; SMN2 (0.71) | MAPTSMN1; SMN2RAB9ALMNAALDH1A1 | |
| SCHEMBL30253337 | 0.81 | KMT2A (0.48) | MEN1MAPTKMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL3298488 | 0.81 | KMT2A (0.48) | MEN1MAPTKMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL7930779 | 0.80 | HDAC1 (0.48) | MEN1MAPTKMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL1483637 | 0.78 | HDAC1 (0.50) | MEN1MAPTKMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL21459993 | 0.78 | FDFT1 (0.49) | MEN1MAPTKMT2AKDM4ENPC1 | |
| SCHEMBL11720766 | 0.78 | KMT2A (0.68) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL1483225 | 0.77 | AR (0.53) | MEN1MAPTKMT2AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018219478-A1 | HETEROARYL-CARBOXAMIDES AS HISTONE DEMETHYLASE INHIBITORS | ORYZON GENOMICS, S.A. (ES) | 2018-12-06 | — | — | WO | disclosed |