Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 11/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | CASP2 | P42575 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20576296 | 0.78 | MEN1 (0.50) | HDAC1HDAC3HDAC6HDAC8HDAC4 | |
| SCHEMBL1483185 | 0.77 | HDAC3 (0.48) | HDAC1HDAC3HDAC6HDAC8HDAC4 | |
| SCHEMBL1483710 | 0.75 | HDAC3 (0.52) | HDAC1HDAC3HDAC6HDAC8HDAC4 | |
| SCHEMBL1484013 | 0.74 | ATM (0.58) | SMN1; SMN2MAPTMEN1KMT2ALMNA | |
| SCHEMBL1484002 | 0.72 | KDM4E (0.55) | HDAC1HDAC3HDAC6HDAC8HDAC4 | |
| SCHEMBL30736094 | 0.72 | GRM5 (0.50) | HDAC1HDAC3HDAC6HDAC8HDAC4 | |
| SCHEMBL1483225 | 0.71 | AR (0.53) | HDAC1HDAC6SMN1; SMN2MAPTKDM4E | |
| SCHEMBL6450357 | 0.71 | NAMPT (0.46) | HDAC1HDAC3HDAC6HDAC8HDAC4 | |
| SCHEMBL11720766 | 0.69 | KMT2A (0.68) | SMN1; SMN2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL3317660 | 0.69 | HDAC3 (0.62) | HDAC1HDAC3HDAC6SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8314103-B2 | Pyridyl derivatives, their preparation and use | Piramal Enterprises Limited (IN) | 2012-11-20 | — | — | US | claimed |
| US-20110077252-A1 | PYRIDYL DERIVATIVES, THEIR PREPARATION AND USE | Piramal Enterprises Limited (IN) | 2011-03-31 | — | — | US | claimed |
| US-8314103-B2 | Pyridyl derivatives, their preparation and use | Piramal Enterprises Limited (IN) | 2012-11-20 | — | — | US | disclosed |
| US-20110077252-A1 | PYRIDYL DERIVATIVES, THEIR PREPARATION AND USE | Piramal Enterprises Limited (IN) | 2011-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110077252-A1 | PYRIDYL DERIVATIVES, THEIR PREPARATION AND USE | HIF1AN, HIF1A, MTOR | HDAC1 761/4885HDAC3 904/4885HDAC6 1970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.