Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | AS3MT | Q9HBK9 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 2/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18282716 | 0.85 | PDE2A (0.71) | PDE2A | |
| SCHEMBL20581457 | 0.84 | PDE2A (0.49) | PDE2A | |
| SCHEMBL20581431 | 0.80 | PDE2A (0.74) | PDE2ASLC6A3GHSRKDM4EALDH1A1 | |
| SCHEMBL6197245 | 0.74 | TSHR (0.50) | MAPTGAATSHRAS3MTGHSR | |
| SCHEMBL3716061 | 0.73 | TSHR (0.43) | PDE2AMAPTGAATSHRAS3MT | |
| SCHEMBL18283117 | 0.71 | PDE2A (0.69) | PDE2AMAPTGHSRADORA2AKDM4E | |
| SCHEMBL22423044 | 0.71 | PDE2A (0.54) | PDE2AGHSR | |
| SCHEMBL18282926 | 0.70 | PDE2A (0.76) | PDE2AGHSR | |
| SCHEMBL20500103 | 0.70 | CTSL (0.41) | GAATSHRAS3MTGHSRCTSL | |
| SCHEMBL20138449 | 0.69 | PDE2A (0.67) | PDE2AGHSRL3MBTL1LMNAGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3634964-B1 | PYRAZOLOPYRIMIDINE PDE9 INHIBITORS | MERCK SHARP & DOHME (US) | 2022-02-23 | — | — | EP | disclosed |
| US-11028092-B2 | Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2021-06-08 | — | — | US | disclosed |
| US-10934294-B2 | Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2021-03-02 | — | — | US | disclosed |
| US-20200140445-A1 | PYRAZOLOPYRIMIDINE PDE9 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-05-07 | — | — | US | disclosed |
| CN-111051308-A | Pyrazolopyrimidine PDE9 inhibitors | 默沙东公司 | 2020-04-21 | — | — | CN | disclosed |
| EP-3634964-A1 | PYRAZOLOPYRIMIDINE PDE9 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2020-04-15 | — | — | EP | disclosed |
| US-20180354955-A1 | PYRAZOLOPYRIMIDINE PDE9 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-12-13 | — | — | US | disclosed |
| WO-2018226771-A1 | PYRAZOLOPYRIMIDINE PDE9 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-12-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934294-B2 | Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors | PDE9A, PDE5A, PDE4D | PDE2A 6/4885MAPT 1894/4885GAA 526/4885 |
| US-20200140445-A1 | PYRAZOLOPYRIMIDINE PDE9 INHIBITORS | PDE9A, PDE5A, PDE2A | PDE2A 3/4885MAPT 2036/4885GAA 341/4885 |
| US-11028092-B2 | Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors | PDE9A, PDE5A, PDE4D | PDE2A 6/4885MAPT 1894/4885GAA 526/4885 |
| US-20180354955-A1 | PYRAZOLOPYRIMIDINE PDE9 INHIBITORS | PDE9A, PDE5A, PDE12 | PDE2A 7/4885MAPT 2290/4885GAA 411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.