Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 3/20 | 0.35 |
| ▸ | PPARD | Q03181 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20590248 | 1.00 | ALDH1A1 (0.38) | ALDH1A1HPGDUSP30CHEK1BTK | |
| SCHEMBL20590287 | 0.97 | ALDH1A1 (0.40) | ALDH1A1HPGDUSP30CHEK1KDM4E | |
| SCHEMBL20590285 | 0.97 | ALDH1A1 (0.40) | ALDH1A1HPGDUSP30CHEK1KDM4E | |
| SCHEMBL28781411 | 0.84 | CHEK1 (0.46) | CHEK1BTKDYRK1A | |
| SCHEMBL5554804 | 0.84 | CHEK1 (0.46) | CHEK1BTKDYRK1A | |
| SCHEMBL19274764 | 0.84 | USP30 (0.55) | USP30BTKPBKCA1CA2 | |
| SCHEMBL19274754 | 0.84 | USP30 (0.55) | USP30BTKPBKCA1CA2 | |
| SCHEMBL20590235 | 0.83 | USP30 (0.36) | ALDH1A1USP30CHEK1BTKGAA | |
| SCHEMBL20590234 | 0.83 | USP30 (0.36) | ALDH1A1USP30CHEK1BTKGAA | |
| SCHEMBL20590295 | 0.82 | PPARA (0.38) | ALDH1A1HPGDUSP30PPARAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3418275-B1 | NOVEL 2,3,5-SUBSTITUTED THIOPHENE COMPOUND AS PROTEIN KINASE INHIBITOR | KOREA INST SCI & TECH (KR) | 2021-03-17 | — | — | EP | disclosed |
| US-10442796-B2 | 2,3,5-substituted thiophene compound as protein kinase inhibitor | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2019-10-15 | — | — | US | disclosed |
| US-20190047993-A1 | Novel 2,3,5-substituted thiophene compound as protein kinase inhibitor | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2019-02-14 | — | — | US | disclosed |
| EP-3418275-A1 | NOVEL 2,3,5-SUBSTITUTED THIOPHENE COMPOUND AS PROTEIN KINASE INHIBITOR | Korea Institute of Science and Technology (KR) | 2018-12-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10442796-B2 | 2,3,5-substituted thiophene compound as protein kinase inhibitor | CDK2, CDK2AP2, MAP3K5 | ALDH1A1 4111/4885HPGD 4081/4885USP30 1820/4885 |
| US-20190047993-A1 | Novel 2,3,5-substituted thiophene compound as protein kinase inhibitor | MAP3K5, MAP3K6, MAP3K9 | ALDH1A1 4145/4885HPGD 4155/4885USP30 1565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.