Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20594824 | 0.89 | STING1 (0.50) | STING1MEN1KMT2AATMSMN1; SMN2 | |
| SCHEMBL20594939 | 0.85 | STING1 (0.69) | STING1MEN1KMT2AATMSMN1; SMN2 | |
| SCHEMBL21990175 | 0.85 | STING1 (0.61) | STING1MEN1KMT2AATMSMN1; SMN2 | |
| SCHEMBL20595101 | 0.82 | CA12 (0.49) | STING1MEN1KMT2AATMSMN1; SMN2 | |
| SCHEMBL25809782 | 0.80 | STING1 (0.72) | STING1MEN1KMT2AATMSMN1; SMN2 | |
| SCHEMBL20594811 | 0.79 | STING1 (0.69) | STING1MEN1KMT2AATMSMN1; SMN2 | |
| SCHEMBL22044779 | 0.79 | STING1 (0.61) | STING1MEN1KMT2AATMSMN1; SMN2 | |
| SCHEMBL22043970 | 0.79 | STING1 (0.61) | STING1MEN1KMT2AATMSMN1; SMN2 | |
| SCHEMBL21972067 | 0.79 | SMN1; SMN2 (0.52) | STING1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL22044387 | 0.77 | STING1 (0.59) | STING1MEN1KMT2AATMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3642197-A1 | HETEROCYCLIC SMALL MOLECULE MODULATORS OF HUMAN STING | Curadev Pharma Limited (GB) | 2020-04-29 | — | — | EP | disclosed |
| WO-2018234807-A1 | HETEROCYCLIC SMALL MOLECULE MODULATORS OF HUMAN STING | CURADEV PHARMA LIMITED (GB) | 2018-12-27 | — | — | WO | disclosed |