Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 5/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | SLC18A2 | Q05940 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.55 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20595751 | 0.91 | CYP2D6 (0.56) | CYP2D6CYP1A2HIF1ASLC18A2LMNA | |
| SCHEMBL20595811 | 0.91 | CYP2D6 (0.56) | CYP2D6CYP1A2HIF1ASLC18A2LMNA | |
| SCHEMBL25969915 | 0.82 | CYP2D6 (0.54) | CYP2D6CYP1A2HIF1ASLC18A2LMNA | |
| SCHEMBL25969912 | 0.82 | CYP2D6 (0.54) | CYP2D6CYP1A2HIF1ASLC18A2LMNA | |
| SCHEMBL6536075 | 0.82 | CYP2D6 (0.54) | CYP2D6CYP1A2HIF1ASLC18A2LMNA | |
| SCHEMBL20595718 | 0.82 | CYP2D6 (0.54) | CYP2D6CYP1A2HIF1ASLC18A2LMNA | |
| SCHEMBL18281715 | 0.81 | MITF (0.52) | CYP2D6CYP1A2HIF1ASLC18A2LMNA | |
| SCHEMBL23236400 | 0.79 | SPHK1 (0.49) | — | |
| SCHEMBL11447464 | 0.79 | CYP2D6 (0.74) | CYP2D6CYP1A2HIF1ASLC18A2LMNA | |
| SCHEMBL18281690 | 0.79 | ATM (0.46) | LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3642182-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR SYNTHESIS | Wave Life Sciences Ltd. (SG) | 2020-04-29 | — | — | EP | disclosed |
| WO-2018237194-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR SYNTHESIS | WAVE LIFE SCIENCES LTD. (SG) | 2018-12-27 | — | — | WO | disclosed |