Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARS2 | Q96GW9 | 9/20 | 0.79 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20595889 | 0.92 | MARS2 (0.79) | MARS2TSHRHTTCYP1A2CYP3A4 | |
| SCHEMBL20595827 | 0.90 | MARS2 (0.81) | MARS2 | |
| SCHEMBL20596139 | 0.89 | MARS2 (0.72) | MARS2P2RX3SMN1; SMN2ALDH1A1 | |
| SCHEMBL20596040 | 0.89 | MARS2 (1.00) | MARS2MEN1KMT2ATSHRCYP1A2 | |
| SCHEMBL20595839 | 0.88 | MARS2 (0.64) | MARS2SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL20595884 | 0.87 | MARS2 (0.86) | MARS2TSHRALDH1A1 | |
| SCHEMBL20595917 | 0.87 | MARS2 (0.80) | MARS2MEN1KMT2ATSHRP2RX3 | |
| SCHEMBL23391517 | 0.86 | MARS2 (0.59) | MARS2MEN1KMT2ATSHRP2RX3 | |
| SCHEMBL30145349 | 0.86 | MARS2 (0.59) | MARS2MEN1KMT2ATSHRP2RX3 | |
| SCHEMBL20596052 | 0.85 | MARS2 (0.80) | MARS2MEN1KMT2ATSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018237349-A1 | INHIBITORS OF TYPED 1 METHIONYL-TRNA SYNTHETASE AND METHODS OF USING THEM | UNIVERSITY OF WASHINGTON (US) | 2018-12-27 | — | — | WO | claimed |