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Sugi Predict / Targets / MARS2

MARS2

Methionine--tRNA ligase, mitochondrial · Q96GW9 · MARS2 on Sugi Atlas →

1,252 patent compounds predicted against MARS2, 870 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL20595908 SCHEMBL20595908 1.00 11/20
SCHEMBL20595911 SCHEMBL20595911 0.85 11/20
SCHEMBL20595846 SCHEMBL20595846 0.82 11/20
SCHEMBL20595910 SCHEMBL20595910 0.80 11/20
SCHEMBL20595839 SCHEMBL20595839 0.64 11/20
SCHEMBL20595961 SCHEMBL20595961 0.63 11/20
SCHEMBL20595876 SCHEMBL20595876 0.61 11/20
SCHEMBL20595921 SCHEMBL20595921 0.60 11/20
SCHEMBL20595951 SCHEMBL20595951 0.74 10/20
SCHEMBL20595855 SCHEMBL20595855 0.51 10/20
SCHEMBL20595873 SCHEMBL20595873 1.00 9/20
SCHEMBL20595902 SCHEMBL20595902 1.00 9/20
SCHEMBL20595884 SCHEMBL20595884 0.86 9/20
SCHEMBL20595827 SCHEMBL20595827 0.81 9/20
SCHEMBL20595832 SCHEMBL20595832 0.81 9/20
SCHEMBL20595964 SCHEMBL20595964 0.81 9/20
SCHEMBL20595917 SCHEMBL20595917 0.80 9/20
SCHEMBL20595889 SCHEMBL20595889 0.79 9/20
SCHEMBL20595950 SCHEMBL20595950 0.79 9/20
SCHEMBL20595966 SCHEMBL20595966 0.77 9/20

Clinical trials — most relevant to MARS2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Administration of Methionine in Patients With Pulmonary Alveolar Proteinosis by Mutation of the MARS Gene. PHASE1/PHASE2COMPLETED
ONC201 in Recurrent/Refractory Metastatic Breast Cancer and Advanced Endometrial Carcinoma PHASE2COMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes (DYNAMMO T2D) EARLY_PHASE1COMPLETED
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence nanNOT_YET_RECRUITING
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide nanRECRUITING
Mitochondrial Dysfunction in Phelan-McDermid Syndrome nanCOMPLETED
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
The Natural History of Mitochondrial Diseases nanRECRUITING
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes nanNOT_YET_RECRUITING
Nicotinamide Riboside and Mitochondrial Biogenesis nanCOMPLETED
Drug Repurposing for Mitochondrial Disorders Using iPSCs Derived Neural Cells nanRECRUITING
Collection of Samples of Bone Marrow Aspiration From Patients With Myelodysplastic Syndrome nanACTIVE_NOT_RECRUITING
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance nanCOMPLETED
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases nanRECRUITING
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study) nanCOMPLETED
Nutritional Assessment in Mitochondrial Cytopathy nanCOMPLETED
Mitochondrial Dysfunctions Driving Insulin Resistance nanCOMPLETED
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione nanCOMPLETED
The Genetics of Diabetes in Southern California Chinese Americans nanWITHDRAWN
Assessing the Role of Mitochondrial Dysfunction in Primary Progressive Multiple Sclerosis nanUNKNOWN
Effect of Branched Chain Amino Acids on Muscle nanCOMPLETED
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC) nanRECRUITING
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy nanCOMPLETED
Clinical Study of Hydroxytyrosol (HT) in Mitochondrial Diseases nanCOMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise nanCOMPLETED
Mitochondrial Disease-associated ImmunoDeficiencies nanRECRUITING
Antioxidants as Adjuvant Therapy to Standard Therapy in Patients With COVID-19 nanCOMPLETED
Impact Of Choline in Patients With NAFLD nanUNKNOWN
Diabetic Cardiomyopathy and Heart Failure nanWITHDRAWN
Impact of Mutations in Aminoacyl tRNA Synthetases on Protein Translation and Cellular Stress nanWITHDRAWN

Related proteins — ESM-2 sequence neighbours (a MARS2 binder may also engage these)

ProteinNameSimilarity
A6H7E1 — 1.000 A6H7E1 →
Q499X9 — 1.000 Q499X9 →
Q90YI3 — 1.000 Q90YI3 →
Q7T0Z0 — 0.995 Q7T0Z0 →
Q9VFL5 — 0.993 Q9VFL5 →
Q9HA77 — 0.992 Q9HA77 →
Q8BYM8 — 0.989 Q8BYM8 →
Q8BIJ6 — 0.989 Q8BIJ6 →
Q6DJ95 — 0.989 Q6DJ95 →
Q6MG21 — 0.989 Q6MG21 →
IARS2 Isoleucine--tRNA ligase, mitochondrial 0.989 landscape →
Q2KIF8 — 0.988 Q2KIF8 →
P49696 — 0.988 P49696 →
Q767M3 — 0.988 Q767M3 →
Q04462 — 0.987 Q04462 →
Q5ST30 — 0.986 Q5ST30 →
Q2T9L8 — 0.986 Q2T9L8 →
Q5JPH6 — 0.986 Q5JPH6 →
Q9M2T9 — 0.986 Q9M2T9 →
Q15031 — 0.985 Q15031 →
VARS1 Valine--tRNA ligase 0.985 landscape →
Q5ZKA2 — 0.984 Q5ZKA2 →
Q9Z1Q9 — 0.984 Q9Z1Q9 →
A0A1D6LAG9 — 0.983 A0A1D6LAG9 →
Q8VDC0 — 0.983 Q8VDC0 →
Q4R646 — 0.982 Q4R646 →
Q9C2H9 — 0.982 Q9C2H9 →
Q6PA41 — 0.982 Q6PA41 →
Q3U2A8 — 0.982 Q3U2A8 →
Q5RCH4 — 0.982 Q5RCH4 →