Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | GAA | P10253 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 8/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | GLA | P06280 | 3/20 | 0.49 |
| ▸ | CASP1 | P29466 | 2/20 | 0.49 |
| ▸ | CASP7 | P55210 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20597270 | 0.89 | NOTUM (0.67) | ALDH1A1GAAKDM4EL3MBTL1NOTUM | |
| SCHEMBL28825316 | 0.82 | NOTUM (0.57) | ALDH1A1GAAKDM4EL3MBTL1NOTUM | |
| SCHEMBL20597377 | 0.81 | NOTUM (0.79) | ALDH1A1GAAKDM4EL3MBTL1NOTUM | |
| SCHEMBL988495 | 0.81 | NOTUM (0.56) | ALDH1A1GAAKDM4EL3MBTL1NOTUM | |
| SCHEMBL20597428 | 0.81 | NOTUM (0.79) | ALDH1A1GAAKDM4EL3MBTL1NOTUM | |
| SCHEMBL20597096 | 0.79 | NOTUM (0.78) | ALDH1A1GAAKDM4EL3MBTL1NOTUM | |
| SCHEMBL20597503 | 0.76 | NOTUM (0.63) | ALDH1A1GAAKDM4EL3MBTL1NOTUM | |
| SCHEMBL20597360 | 0.73 | NOTUM (0.63) | ALDH1A1GAAKDM4EL3MBTL1NOTUM | |
| SCHEMBL20597320 | 0.73 | MAPT (0.56) | ALDH1A1GAAKDM4EL3MBTL1NOTUM | |
| SCHEMBL989468 | 0.72 | NOTUM (0.72) | ALDH1A1GAAKDM4EL3MBTL1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2714675-B1 | 4H-THIENO[3,2-C]CHROMENE-BASED INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2019-01-02 | — | — | EP | disclosed |