Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.56 |
| ▸ | GAA | P10253 | 7/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 6/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 3/20 | 0.50 |
| ▸ | CASP1 | P29466 | 2/20 | 0.50 |
| ▸ | CASP7 | P55210 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL988495 | 0.85 | NOTUM (0.56) | NOTUMALDH1A1GAAKDM4EL3MBTL1 | |
| SCHEMBL20597428 | 0.85 | NOTUM (0.79) | NOTUMALDH1A1GAAKDM4EL3MBTL1 | |
| SCHEMBL20597377 | 0.85 | NOTUM (0.79) | NOTUMALDH1A1GAAKDM4EL3MBTL1 | |
| SCHEMBL20597096 | 0.83 | NOTUM (0.78) | NOTUMALDH1A1GAAKDM4EL3MBTL1 | |
| SCHEMBL20596995 | 0.82 | ALDH1A1 (0.55) | NOTUMALDH1A1GAAKDM4EL3MBTL1 | |
| SCHEMBL20597503 | 0.80 | NOTUM (0.63) | NOTUMALDH1A1GAAKDM4EL3MBTL1 | |
| SCHEMBL989618 | 0.78 | PIK3CA (0.64) | NOTUMALDH1A1GAAKDM4EL3MBTL1 | |
| SCHEMBL20597360 | 0.77 | NOTUM (0.63) | NOTUMALDH1A1GAAKDM4EL3MBTL1 | |
| SCHEMBL14811998 | 0.76 | MAPT (0.50) | NOTUMALDH1A1GAAKDM4EHPGD | |
| SCHEMBL20597485 | 0.74 | PIK3CA (0.52) | NOTUMALDH1A1GAAKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102333779-B | Benzopyran and benzoxex PI3K inhibitor compounds and methods of use | GENENTECH, INC. (US) | 2015-12-09 | — | — | CN | disclosed |