⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9963859 | 0.79 | — | — | |
| SCHEMBL294748 | 0.76 | — | — | |
| SCHEMBL23346791 | 0.73 | — | — | |
| SCHEMBL2100535 | 0.72 | CYP2B6 (0.30) | — | |
| SCHEMBL444936 | 0.67 | GRIN2D (0.37) | — | |
| SCHEMBL6663337 | 0.65 | GRIN2D (0.39) | — | |
| SCHEMBL16219371 | 0.65 | CRHBP (0.31) | — | |
| SCHEMBL15248832 | 0.65 | GRIN2D (0.39) | — | |
| SCHEMBL19542912 | 0.65 | GRIN2D (0.39) | — | |
| SCHEMBL278410 | 0.65 | GRIN2D (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118302411-A | Therapeutic indazole compounds and methods of use thereof for the treatment of cancer | 基因泰克公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-114269756-B | 4-Oxo-3, 4-dihydropyrido [3,4-D ] pyrimidine compounds that inhibit EIF4E | 效应疗法股份有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-116987020-A | Protease inhibitor and preparation method and application thereof | 清华大学 | 2023-11-03 | — | — | CN | disclosed |
| CN-116802184-A | Pyrazolothiazole carboxamides and their use as PDGFR inhibitors | 埃科特莱茵药品有限公司 | 2023-09-22 | — | — | CN | disclosed |
| CN-111465602-B | Synthesis of 4-aminopyrimidine compounds | 帕劳制药有限公司 | 2023-05-23 | — | — | CN | disclosed |
| CN-111465602-B | Synthesis of 4-aminopyrimidine compounds | 帕劳制药有限公司 | 2023-05-23 | — | — | CN | disclosed |
| CN-115916770-A | H4 antagonist compounds | 赫普泰雅治疗有限公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-115835908-A | Bicyclic heterocycles as FGFR inhibitors | 因赛特公司 | 2023-03-21 | — | — | CN | disclosed |
| US-11548890-B1 | HPK1 antagonists and uses thereof | Nimbus Saturn, Inc. (US) | 2023-01-10 | — | — | US | disclosed |
| CN-115151533-A | MEK inhibitors and therapeutic uses thereof | 医疗免疫工程公司 | 2022-10-04 | — | — | CN | disclosed |
| CN-114981241-A | Novel compound, preparation method and application thereof | 大邱庆北尖端医疗产业振兴财团 | 2022-08-30 | — | — | CN | disclosed |
| CN-114728936-A | Bifunctional compounds for the treatment of cancer | 豪夫迈·罗氏有限公司 | 2022-07-08 | — | — | CN | disclosed |
| CN-113993868-A | Substituted pyrazolopyridinamides and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2022-01-28 | — | — | CN | disclosed |
| WO-2021066088-A1 | NOVEL TRIAZINE DERIVATIVE | Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 | 2021-04-08 | — | — | WO | disclosed |
| CN-112204032-A | Heterocyclic derivatives and use thereof | C&C新药研究所 | 2021-01-08 | — | — | CN | disclosed |
| CN-112041313-A | Pyridine-sulfonamide compounds and their use against pain and related conditions | 基因泰克公司 | 2020-12-04 | — | — | CN | disclosed |
| CN-111465602-A | Synthesis of 4-aminopyrimidine compounds | 森索睿翁公司 | 2020-07-28 | — | — | CN | disclosed |
| CN-111465602-A | Synthesis of 4-aminopyrimidine compounds | 森索睿翁公司 | 2020-07-28 | — | — | CN | disclosed |
| US-10703756-B2 | Pyrrolo[2,3-D]pyrimidinyl, pyrrolo[2,3-B]pyrazinyl, pyrrolo[2,3-B]pyridinyl acrylamides and epoxides thereof | PFIZER INC. (US) | 2020-07-07 | — | — | US | disclosed |
| US-20190002466-A1 | PYRROLO[2,3-D]PYRIMIDINYL, PYRROLO[2,3-B]PYRAZINYL, PYRROLO[2,3-B]PYRIDINYL ACRYLAMIDES AND EPOXIDES THEREOF | PFIZER INC. (US) | 2019-01-03 | — | — | US | disclosed |