Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP13 | P45452 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL595032 | 0.87 | GAA (0.51) | SMN1; SMN2POLBGAACHRM1PDE4B | |
| SCHEMBL9790049 | 0.87 | GAA (0.51) | SMN1; SMN2POLBGAACHRM1PDE4B | |
| SCHEMBL9790042 | 0.87 | GAA (0.51) | SMN1; SMN2POLBGAACHRM1PDE4B | |
| SCHEMBL400027 | 0.87 | GAA (0.51) | SMN1; SMN2POLBGAACHRM1PDE4B | |
| SCHEMBL595031 | 0.87 | GAA (0.51) | SMN1; SMN2POLBGAACHRM1PDE4B | |
| Hydrochloric Acid SCHEMBL4762541 | 0.86 | GAA (0.50) | SMN1; SMN2POLBGAACHRM1PDE4B | |
| SCHEMBL31164175 | 0.83 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNAPOLBGAACHRM1 | |
| SCHEMBL20598929 | 0.83 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNAPOLBGAACHRM1 | |
| SCHEMBL3635383 | 0.82 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAPOLBGAACHRM1 | |
| SCHEMBL30380343 | 0.82 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAPOLBGAACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10703756-B2 | Pyrrolo[2,3-D]pyrimidinyl, pyrrolo[2,3-B]pyrazinyl, pyrrolo[2,3-B]pyridinyl acrylamides and epoxides thereof | PFIZER INC. (US) | 2020-07-07 | — | — | US | disclosed |
| US-20190002466-A1 | PYRROLO[2,3-D]PYRIMIDINYL, PYRROLO[2,3-B]PYRAZINYL, PYRROLO[2,3-B]PYRIDINYL ACRYLAMIDES AND EPOXIDES THEREOF | PFIZER INC. (US) | 2019-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190002466-A1 | PYRROLO[2,3-D]PYRIMIDINYL, PYRROLO[2,3-B]PYRAZINYL, PYRROLO[2,3-B]PYRIDINYL ACRYLAMIDES AND EPOXIDES THEREOF | JAK2, JAK3, JAK1 | SMN1; SMN2 4446/4885LMNA 4500/4885POLB 1056/4885 |
| US-10703756-B2 | Pyrrolo[2,3-D]pyrimidinyl, pyrrolo[2,3-B]pyrazinyl, pyrrolo[2,3-B]pyridinyl acrylamides and epoxides thereof | JAK2, JAK3, JAK1 | SMN1; SMN2 4446/4885LMNA 4500/4885POLB 1056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.