Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9806822 | 0.86 | ALDH1A1 (0.71) | ALDH1A1KMT2AMEN1MAPTHTT | |
| SCHEMBL11591761 | 0.86 | ALDH1A1 (0.71) | ALDH1A1KMT2AMEN1MAPTHTT | |
| SCHEMBL1441063 | 0.86 | ALDH1A1 (0.71) | ALDH1A1KMT2AMEN1MAPTHTT | |
| SCHEMBL11807272 | 0.86 | ALDH1A1 (0.71) | ALDH1A1KMT2AMEN1MAPTHTT | |
| SCHEMBL18888 | 0.86 | ALDH1A1 (0.71) | ALDH1A1KMT2AMEN1MAPTHTT | |
| SCHEMBL15443062 | 0.86 | ALDH1A1 (0.71) | ALDH1A1KMT2AMEN1MAPTHTT | |
| SCHEMBL26035422 | 0.86 | ALDH1A1 (0.46) | ALDH1A1TDP1KMT2AMEN1MAPT | |
| Hydrochloric Acid SCHEMBL4282507 | 0.84 | ALDH1A1 (0.69) | ALDH1A1KMT2AMEN1MAPTHTT | |
| SCHEMBL18367 | 0.84 | ALDH1A1 (0.68) | ALDH1A1KMT2AMEN1MAPTHTT | |
| Bicarbonate SCHEMBL9233185 | 0.82 | ALDH1A1 (0.67) | ALDH1A1KMT2AMEN1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3645516-A1 | HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS | Janssen Pharmaceutica NV (BE) | 2020-05-06 | — | — | EP | disclosed |
| WO-2019001420-A1 | HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS | JANSSEN PHARMACEUTICA NV (BE) | 2019-01-03 | — | — | WO | disclosed |