Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | TEAD4 | Q15561 | 11/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.42 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.42 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20601560 | 1.00 | HDAC3 (0.47) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL20624680 | 1.00 | HDAC3 (0.47) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL20624608 | 1.00 | HDAC3 (0.47) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL20624408 | 1.00 | HDAC3 (0.47) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL20624406 | 1.00 | HDAC3 (0.47) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL20624411 | 1.00 | HDAC3 (0.47) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL20601510 | 0.99 | TEAD4 (0.47) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL20601842 | 0.92 | GPR84 (0.55) | TEAD4GPR84FFAR1TEAD1TEAD2 | |
| SCHEMBL21887783 | 0.84 | TEAD4 (0.49) | TEAD4GPR84FFAR1TEAD1TEAD2 | |
| SCHEMBL21887350 | 0.80 | FFAR1 (0.51) | TEAD4GPR84FFAR1TEAD1TEAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019003237-A1 | INDOLYLKOJYL METHANE ANALOGUES, PROCESS OF PREPARATION THEREOF AND USE AS INHIBITOR OF CANCER CELL INVASION AND METASTASIS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2019-01-03 | — | — | WO | claimed |
| US-11180486-B2 | Indolylkojyl methane analogues, process of preparation thereof and use as inhibitor of cancer cells invasion and metastasis | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2021-11-23 | — | — | US | disclosed |
| US-11180486-B2 | Indolylkojyl methane analogues, process of preparation thereof and use as inhibitor of cancer cells invasion and metastasis | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2021-11-23 | — | — | US | disclosed |
| US-20200115365-A1 | INDOLYLKOJYL METHANE ANALOGUES, PROCESS OF PREPARATION THEREOF AND USE AS INHIBITOR OF CANCER CELLS INVASION AND METASTASIS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2020-04-16 | — | — | US | disclosed |
| US-20200115365-A1 | INDOLYLKOJYL METHANE ANALOGUES, PROCESS OF PREPARATION THEREOF AND USE AS INHIBITOR OF CANCER CELLS INVASION AND METASTASIS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2020-04-16 | — | — | US | disclosed |
| WO-2019003237-A1 | INDOLYLKOJYL METHANE ANALOGUES, PROCESS OF PREPARATION THEREOF AND USE AS INHIBITOR OF CANCER CELL INVASION AND METASTASIS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2019-01-03 | — | — | WO | disclosed |
| WO-2019003237-A1 | INDOLYLKOJYL METHANE ANALOGUES, PROCESS OF PREPARATION THEREOF AND USE AS INHIBITOR OF CANCER CELL INVASION AND METASTASIS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2019-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200115365-A1 | INDOLYLKOJYL METHANE ANALOGUES, PROCESS OF PREPARATION THEREOF AND USE AS INHIBITOR OF CANCER CELLS INVASION AND METASTASIS | MIF, CYP11B1, CCNI | HDAC3 3862/4885HDAC1 3200/4885HDAC2 3860/4885 |
| US-11180486-B2 | Indolylkojyl methane analogues, process of preparation thereof and use as inhibitor of cancer cells invasion and metastasis | MIF, CYP11B1, MKI67 | HDAC3 3870/4885HDAC1 3019/4885HDAC2 3858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.