Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | FNTA | P49354 | 1/20 | 0.31 |
| ▸ | FNTB | P49356 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31336451 | 0.70 | PDK2 (0.31) | — | |
| SCHEMBL28703494 | 0.64 | — | — | |
| SCHEMBL28360296 | 0.63 | — | — | |
| SCHEMBL29357157 | 0.60 | CA1 (0.32) | ATM | |
| SCHEMBL1903369 | 0.56 | NOTUM (0.50) | MAPK1MAPK14 | |
| Iodide SCHEMBL28741644 | 0.55 | NOTUM (0.48) | MAPK1MAPK14 | |
| Hydrochloric Acid SCHEMBL29948123 | 0.55 | NOTUM (0.48) | MAPK1MAPK14 | |
| SCHEMBL4757678 | 0.54 | KMT2A (0.35) | MAPK1 | |
| SCHEMBL21742559 | 0.53 | NOTUM (0.52) | MAPK14 | |
| SCHEMBL21742498 | 0.53 | MAPK14 (0.46) | MAPK1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019008156-A1 | INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2019-01-10 | — | — | WO | disclosed |