Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19638580 | 0.87 | EPHX2 (0.40) | KMT2AMEN1ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL5289688 | 0.79 | ALDH1A1 (0.36) | KMT2AMEN1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL6710688 | 0.79 | TSHR (0.32) | KMT2AMEN1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL5150393 | 0.76 | KMT2A (0.40) | KMT2AMEN1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL23748559 | 0.75 | NPC1 (0.33) | KMT2AMEN1LMNANPC1MAPT | |
| SCHEMBL31303806 | 0.72 | — | — | |
| SCHEMBL17685851 | 0.71 | SLC1A3 (0.37) | KMT2AMEN1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL1134295 | 0.70 | MAPT (0.35) | KMT2AMEN1ALDH1A1TSHRMAPT | |
| SCHEMBL3416734 | 0.68 | TSHR (0.35) | KMT2AMEN1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL5029772 | 0.67 | SLC1A3 (0.37) | KMT2AMEN1SLC1A3SLC1A2SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001844-A2 | BICYCLIC CARBOXYLIC ACID DERIVATIVES USEFUL FOR TREATING METABOLIC DISORDERS | Amgen, Inc (US) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007106469-A2 | BICYCLIC CARBOXYLIC ACID DERIVATIVES USEFUL FOR TREATING METABOLIC DISORDERS | AMGEN INC. (US) | 2007-09-20 | — | — | WO | disclosed |