⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16654119 | 0.79 | FGFR3 (0.35) | — | |
| SCHEMBL16654403 | 0.75 | FGFR4 (0.41) | — | |
| SCHEMBL16665253 | 0.74 | FGFR1 (0.33) | — | |
| SCHEMBL16655847 | 0.72 | FGFR4 (0.42) | — | |
| SCHEMBL16655790 | 0.70 | FGFR1 (0.44) | — | |
| SCHEMBL22157649 | 0.70 | FGFR4 (0.32) | — | |
| SCHEMBL16659627 | 0.68 | FGFR3 (0.33) | — | |
| SCHEMBL28767434 | 0.68 | FGFR1 (0.33) | — | |
| SCHEMBL28767438 | 0.67 | FGFR3 (0.42) | — | |
| SCHEMBL28768907 | 0.66 | FGFR3 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3421457-B1 | PYRIMIDINE FGFR4 INHIBITORS | EISAI R&D MAN CO LTD (JP) | 2021-10-06 | — | — | EP | disclosed |
| EP-3421457-A1 | PYRIMIDINE FGFR4 INHIBITORS | Eisai R&D Management Co., Ltd. (JP) | 2019-01-02 | — | — | EP | disclosed |