Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.54 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.54 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | CD38 | P28907 | 9/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20612933 | 0.89 | NPC1 (0.52) | TAS1R3TAS1R1TAS1R2RAB9ANPC1 | |
| SCHEMBL20612991 | 0.83 | CD38 (0.48) | TAS1R3TAS1R1TAS1R2RAB9ANPC1 | |
| SCHEMBL20612913 | 0.82 | CD38 (0.75) | CD38 | |
| SCHEMBL20613026 | 0.81 | CD38 (0.57) | CD38 | |
| SCHEMBL20613021 | 0.81 | CD38 (0.57) | CD38 | |
| SCHEMBL20612996 | 0.78 | CD38 (0.54) | CD38 | |
| SCHEMBL24494420 | 0.75 | KMT2A (0.44) | TAS1R3TAS1R1TAS1R2RAB9ACD38 | |
| SCHEMBL31106432 | 0.74 | KEAP1 (0.57) | RAB9ANPC1CD38LMNA | |
| SCHEMBL20612910 | 0.73 | NPC1 (0.51) | RAB9ANPC1CD38CNR2LMNA | |
| SCHEMBL20596894 | 0.73 | IRAK4 (0.48) | RAB9ANPC1CD38 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3227275-B1 | CD38 INHIBITORS AND METHODS OF TREATMENT | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2019-01-02 | — | — | EP | disclosed |