Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 12/20 | 0.56 |
| ▸ | RARB | P10826 | 12/20 | 0.56 |
| ▸ | RARG | P13631 | 12/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | IKBKB | O14920 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL206518 | 0.90 | RARA (0.55) | RARARARBRARGSMN1; SMN2IKBKB | |
| SCHEMBL17059011 | 0.84 | RARA (0.50) | RARARARBRARGSMN1; SMN2IKBKB | |
| SCHEMBL206232 | 0.78 | TOP2A (0.56) | SMN1; SMN2IKBKBKDM4EALDH1A1TSHR | |
| SCHEMBL206175 | 0.77 | SMN1; SMN2 (0.48) | RARARARBRARGSMN1; SMN2IKBKB | |
| SCHEMBL206517 | 0.77 | NPC1 (0.50) | SMN1; SMN2IKBKBKDM4EALDH1A1CYP1A2 | |
| SCHEMBL205006 | 0.76 | RARA (0.46) | RARARARBRARGSMN1; SMN2IKBKB | |
| SCHEMBL18873093 | 0.74 | RARA (0.50) | RARARARBRARGSMN1; SMN2KDM4E | |
| SCHEMBL11565318 | 0.74 | SMN1; SMN2 (0.59) | SMN1; SMN2KDM4EALDH1A1TSHRHSD17B10 | |
| SCHEMBL4966627 | 0.73 | MCL1 (0.70) | SMN1; SMN2KDM4EALDH1A1DHODH | |
| SCHEMBL2964683 | 0.72 | MAPT (0.47) | SMN1; SMN2IKBKBKDM4EALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088760-B2 | Benzoxazole carboxamide inhibitors of poly(ADP-ribose)polymerase (PARP) | BIOMARIN PHARMACEUTICAL INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-20090197863-A1 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | LEAD THERAPEUTICS, INC. (US) | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197863-A1 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | PARP1, PARP2, PARP11 | RARA 1951/4885RARB 2137/4885RARG 2090/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.