SCHEMBL206196

SCHEMBL206196

N[C@@H](Cc1ccccc1)C(=O)OCP(=O)(O)O

nearest known ligand 0.57

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
LAP3 P28838 5/20 0.57
ANPEP P15144 4/20 0.57
ALPI P09923 1/20 0.56
PKM P14618 1/20 0.56
PTGS1 P23219 1/20 0.56
XIAP P98170 1/20 0.56
SLC7A5 Q01650 1/20 0.56
SLC15A1 P46059 1/20 0.49
ACP3 P15309 1/20 0.47
PTPRC P08575 1/20 0.47
LTA4H P09960 1/20 0.46
ERAP1 Q9NZ08 2/20 0.46
ERAP2 Q6P179 1/20 0.46
PTPN1 P18031 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9137964 0.86 ALPI (0.51) LAP3ANPEPALPIPKMPTGS1
SCHEMBL9140740 0.85 ALPI (0.50) LAP3ANPEPALPIPKMPTGS1
SCHEMBL9242132 0.84 LAP3 (0.54) LAP3ANPEPALPIPKMPTGS1
SCHEMBL5307576 0.83 ALPI (0.51) LAP3ANPEPALPIPKMPTGS1
SCHEMBL4958184 0.82 ALPI (0.58) LAP3ANPEPALPIPKMPTGS1
SCHEMBL18025352 0.81 SLC7A5 (0.66) LAP3ANPEPALPIPKMPTGS1
SCHEMBL26359430 0.81 ALPI (0.66) ALPIPKMPTGS1XIAPSLC7A5
SCHEMBL15679078 0.81 ALPI (0.66) ALPIPKMPTGS1XIAPSLC7A5
SCHEMBL2785098 0.81 SLC7A5 (0.70) LAP3ANPEPALPIPKMPTGS1
Phenylalanine Methyl Ester SCHEMBL9355493 0.81 LAP3 (0.58) LAP3ANPEPALPIPKMPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7132392-B1 Inhibition of cell motility and angiogenesis by inhibitors of Grb2-SH2-domain THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2006-11-07 US claimed
EP-1140980-B1 PSEUDOPEPTIDE COMPOUNDS HAVING AN INHIBITING ACTIVITY WITH RESPECT TO PATHS ACTIVATED BY PROTEINS WITH ACTIVE TYROSINE KINASE ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME INST NAT SANTE RECH MED (FR) 2004-09-29 EP claimed
EP-1223959-A2 INHBITION OF CELL MOTILITY AND ANGIOGENESIS BY INHIBITORS OF THE GRB2 SH2-DOMAIN THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2002-07-24 EP claimed
US-6307090-B1 OXALYL ENDCAPPED; CONTAINING A BIVALENT RADICAL OF PHOSPHOTYROSINE OR A PHOSPHOTYROSINE MIMETIC THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES 2001-10-23 US claimed
WO-2001028577-A2 INHIBITION OF CELL MOTILITY AND ANGIOGENESIS BY INHIBITORS OF THE GRB2 SH2-DOMAIN THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2001-04-26 WO claimed
CN-114127272-B Engineered imine reductase and methods for reductive amination of ketone and amine compounds 科德克希思公司 2025-05-27 CN disclosed
CN-114555795-B Ketoreductase polypeptides and polynucleotides 科德克希思公司 2025-05-27 CN disclosed
CN-114096662-B Engineered glucose dehydrogenase and method for reductive amination of ketone and amine compounds 科德克希思公司 2025-04-15 CN disclosed
CN-113396218-B Engineered transaminase polypeptides 科德克希思公司 2025-02-18 CN disclosed
CN-118871576-A Engineered monoamine oxidase for preparing stereoisomerically pure fused bicyclic proline compounds 科德克希思公司 2024-10-29 CN disclosed
CN-118647711-A Engineered enone reductase and ketoreductase variant enzymes 科德克希思公司 2024-09-13 CN disclosed
CN-118369421-A Engineered threonine aldolase and amino acid decarboxylase 科德克希思公司 2024-07-19 CN disclosed
US-5770620-A ENZYME INHIBITOR AS IMMUNOMODULATORS ONTOGEN CORPORATION (US) 1998-06-23 US disclosed
EP-0847443-A1 CRYSTALLINE ZAP FAMILY PROTEINS ARIAD PHARMACEUTICALS, INC. (US) 1998-06-17 EP disclosed
US-5753687-A ACRYLATED ARYLIMIDAZOLE DERIVATIVES ONTOGEN CORPORATION (US) 1998-05-19 US disclosed
WO-1997039748-A1 MODULATORS OF MOLECULES WITH PHOSPHOTYROSINE RECOGNITION UNITS NOVO NORDISK A/S (DK) 1997-10-30 WO disclosed
WO-1997040017-A2 MODULATORS OF MOLECULES WITH PHOSPHOTYROSINE RECOGNITION UNITS NOVO NORDISK A/S (DK) 1997-10-30 WO disclosed
WO-1997008300-A1 CRYSTALLINE ZAP FAMILY PROTEINS ARIAD PHARMACEUTICALS, INC. (US) 1997-03-06 WO disclosed
US-5475129-A Phosphonoalkyl phenylalanine compounds suitably protected for use in peptide synthesis THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1995-12-12 US disclosed
WO-1993025561-A1 PHOSPHONOALKYL PHENYLALANINE COMPOUNDS SUITABLY PROTECTED FOR USE IN PEPTIDE SYNTHESIS THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1993-12-23 WO disclosed