Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 4/20 | 0.54 |
| ▸ | EHMT2 | Q96KQ7 | 5/20 | 0.53 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.49 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.49 |
| ▸ | SPIN1 | Q9Y657 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.43 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.43 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | WHR1 | P49842 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20620893 | 1.00 | NSD2 (0.54) | NSD2EHMT2KDM1ARCOR1DNMT3A | |
| SCHEMBL29453051 | 0.90 | KMT5A (0.55) | NSD2EHMT2KDM1ARCOR1KMT5A | |
| SCHEMBL20620934 | 0.90 | KMT5A (0.55) | NSD2EHMT2KDM1ARCOR1KMT5A | |
| SCHEMBL22084192 | 0.90 | KMT5A (0.55) | NSD2EHMT2KDM1ARCOR1KMT5A | |
| SCHEMBL20620894 | 0.86 | NSD2 (0.53) | NSD2EHMT2KDM1ARCOR1DNMT3A | |
| SCHEMBL20620897 | 0.86 | NSD2 (0.53) | NSD2EHMT2KDM1ARCOR1DNMT3A | |
| SCHEMBL20621265 | 0.80 | KMT5A (0.62) | NSD2EHMT2KMT5AWHR1 | |
| SCHEMBL29453059 | 0.80 | KMT5A (0.62) | NSD2EHMT2KMT5AWHR1 | |
| SCHEMBL22026560 | 0.79 | EHMT2 (0.58) | EHMT2WHR1 | |
| SCHEMBL20602882 | 0.79 | EHMT2 (0.58) | EHMT2WHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019006322-A1 | HETEROCHROMATIN GENE REPRESSION INHIBITORS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2019-01-03 | — | — | WO | disclosed |