SCHEMBL20624151

SCHEMBL20624151

O=C1c2c(c3c4ccccc4n(CCc4ccccc4)c3c3[nH]c4ccccc4c23)C(=O)N1CCO

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 4/20 0.62
CCND1 P24385 4/20 0.62
CCNE2 O96020 2/20 0.62
CCNE1 P24864 2/20 0.62
CDK2 P24941 2/20 0.62
PRKCA P17252 7/20 0.56
PRKD3 O94806 4/20 0.56
PRKCG P05129 4/20 0.56
PRKCB P05771 4/20 0.56
PRKCH P24723 4/20 0.56
PRKCI P41743 4/20 0.56
PRKCE Q02156 4/20 0.56
PRKCQ Q04759 4/20 0.56
PRKCZ Q05513 4/20 0.56
PRKCD Q05655 4/20 0.56
PRKD1 Q15139 4/20 0.56
NQO1 P15559 1/20 0.54
PRKACA P17612 2/20 0.52
PRKACG P22612 2/20 0.52
PRKACB P22694 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20624153 0.94 CDK4 (0.68) CDK4CCND1CCNE2CCNE1CDK2
SCHEMBL20624148 0.93 CDK4 (0.60) CDK4CCND1CCNE2CCNE1CDK2
SCHEMBL20624183 0.90 PRKCA (0.56) CDK4CCND1CCNE2CCNE1CDK2
SCHEMBL20624206 0.88 CDK4 (0.55) CDK4CCND1CCNE2CCNE1CDK2
SCHEMBL20624167 0.88 PRKCA (0.69) CDK4CCND1CCNE2CCNE1CDK2
SCHEMBL20624166 0.87 PRKCA (0.63) CDK4CCND1CCNE2CCNE1CDK2
SCHEMBL20624150 0.87 NQO1 (0.54) CDK4CCND1CCNE2CCNE1CDK2
SCHEMBL20623435 0.86 CDK4 (0.58) CDK4CCND1CCNE2CCNE1CDK2
SCHEMBL20624186 0.85 PRKD3 (0.52) CDK4CCND1CCNE2CCNE1CDK2
SCHEMBL20624182 0.85 CDK4 (0.56) CDK4CCND1CCNE2CCNE1CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019000224-A1 BISINDOLYLMALEIMIDE DERIVATIVE AND PREPARATION METHOD AND USE THEREOF 中国海洋大学 2019-01-03 WO disclosed