Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 3/20 | 0.68 |
| ▸ | ACHE | P22303 | 2/20 | 0.68 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.37 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18961290 | 0.81 | BCHE (1.00) | BCHEACHEPDPK1MTORPSEN1 | |
| SCHEMBL24376571 | 0.81 | BCHE (1.00) | BCHEACHEPDPK1MTORPSEN1 | |
| SCHEMBL17925924 | 0.75 | BCHE (0.62) | BCHEACHEPDPK1MTORPSEN1 | |
| SCHEMBL23995897 | 0.75 | BCHE (0.62) | BCHEACHEPDPK1MTORPSEN1 | |
| SCHEMBL4182846 | 0.73 | BCHE (0.59) | BCHEACHEPDPK1MTORPSEN1 | |
| SCHEMBL18716356 | 0.73 | BCHE (0.50) | BCHEACHEPSEN1PSEN2APH1B | |
| SCHEMBL21944472 | 0.70 | BCHE (0.53) | BCHEACHEPSEN1PSEN2APH1B | |
| SCHEMBL18686920 | 0.70 | BCHE (0.53) | BCHEACHEPSEN1PSEN2APH1B | |
| SCHEMBL2887472 | 0.70 | BCHE (0.55) | BCHEACHEPDPK1MTORPSEN1 | |
| SCHEMBL3818662 | 0.70 | BCHE (0.55) | BCHEACHEPDPK1MTORPSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10174054-B2 | Compounds and methods for the treatment of Alzheimer's disease and/or cerebral amyloid angiopathy | AMICUS THERAPEUTICS, INC. (US) | 2019-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10174054-B2 | Compounds and methods for the treatment of Alzheimer's disease and/or cerebral amyloid angiopathy | APP, PSEN1, PSEN2 | BCHE 23/4885ACHE 85/4885PDPK1 2227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.