SCHEMBL20627092

SCHEMBL20627092

Nc1ncc(-c2ccc(-c3ccccc3S(=O)(=O)NCC(F)(F)F)cn2)cn1

nearest known ligand 0.73

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FEN1 P39748 20/20 0.73
ALOX5AP P20292 19/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15917241 0.85 FEN1 (1.00) FEN1ALOX5AP
Trifluoroacetic Acid SCHEMBL15917173 0.84 ALOX5AP (0.84) FEN1ALOX5AP
SCHEMBL20627276 0.84 FEN1 (0.77) FEN1ALOX5AP
SCHEMBL19840182 0.84 ALOX5AP (0.81) FEN1ALOX5AP
SCHEMBL15916017 0.81 ALOX5AP (1.00) FEN1ALOX5AP
SCHEMBL20538639 0.81 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15916097 0.81 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15917896 0.81 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL20538677 0.80 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15918565 0.80 FEN1 (1.00) FEN1ALOX5AP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3495359-A1 FLAP MODULATORS Janssen Pharmaceutica NV (BE) 2019-06-12 EP disclosed
EP-3070085-B1 FLAP MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2019-01-09 EP disclosed