Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TAS2R38 | P59533 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | TYR | P14679 | 1/20 | 0.45 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18743590 | 0.81 | ALDH1A1 (0.48) | MAPTGAAALDH1A1TP53NPC1 | |
| SCHEMBL18676599 | 0.80 | ALDH1A1 (0.41) | MAPTGAAKDM4EHPGDTAS2R38 | |
| SCHEMBL18743478 | 0.80 | POLB (0.42) | MAPTGAAKDM4EHPGDTAS2R38 | |
| SCHEMBL24235482 | 0.80 | MAPT (0.48) | MAPTGAAKDM4EHPGDTAS2R38 | |
| SCHEMBL18743593 | 0.80 | IDO1 (0.47) | MAPTGAAKDM4EHPGDALDH1A1 | |
| SCHEMBL18743511 | 0.79 | GAA (0.42) | MAPTGAAKDM4EHPGDTAS2R38 | |
| SCHEMBL18743595 | 0.79 | PARP1 (0.66) | ALDH1A1PARP1KMT2AMEN1 | |
| SCHEMBL18743037 | 0.78 | ALDH1A1 (0.42) | MAPTGAATAS2R38HSD17B10ALDH1A1 | |
| SCHEMBL18743373 | 0.78 | ALDH1A1 (0.39) | MAPTGAAKDM4EHPGDTAS2R38 | |
| SCHEMBL18743035 | 0.77 | MEN1 (0.46) | MAPTGAAKDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3125884-B1 | SMALL MOLECULE INHIBITORS OF MCL-1 AND USES THEREOF | UNIV MICHIGAN REGENTS (US) | 2019-11-06 | — | — | EP | disclosed |
| EP-3424924-A1 | UREA COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | Ancureall Pharmaceutical (Shanghai) Co., Ltd. (CN) | 2019-01-09 | — | — | EP | disclosed |